| Title | Role of the ESAT-6 secretion system in virulence of the emerging community-associated Staphylococcus aureus lineage ST398 |
| Authors | Wang, Yanan Hu, Mo Liu, Qian Qin, Juanxiu Dai, Yingxin He, Lei Li, Tianming Zheng, Bing Zhou, Fan Yu, Kaiwen Fang, Jingyuan Liu, Xiaoyun Otto, Michael Li, Min |
| Affiliation | Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Lab Med, Shanghai 200127, Peoples R China. Peking Univ, Coll Chem & Mol Engn, Inst Analyt Chem, Beijing 100871, Peoples R China. Peking Univ, Coll Chem & Mol Engn, Synthet & Funct Biomol Ctr, Beijing 100871, Peoples R China. Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Div Gastroenterol & Hepatol, Shanghai 200127, Peoples R China. Shanghai Inst Digest Dis, Shanghai 200127, Peoples R China. NIAID, Bacteriol Lab, Pathogen Mol Genet Sect, NIH, Bethesda, MD 20892 USA. Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Lab Med, Shanghai 200127, Peoples R China. Otto, M (reprint author), NIAID, Bacteriol Lab, Pathogen Mol Genet Sect, NIH, Bethesda, MD 20892 USA. |
| Keywords | METHICILLIN-RESISTANT INFECTIONS EPIDEMIOLOGY PATHOGENESIS PNEUMONIA PROTEINS |
| Issue Date | 2016 |
| Publisher | SCIENTIFIC REPORTS |
| Citation | SCIENTIFIC REPORTS.2016,6. |
| Abstract | Novel Staphylococcus aureus clones continue to emerge that cause infections in otherwise healthy people. One example is the sequence type (ST) 398 lineage, which we show here is increasing in importance as a significant cause of community-associated (CA) human infections in China. We have a profound lack of understanding about what determines the considerable virulence potential of such newly emerging clones. Information about the contribution to virulence of the more recently discovered ESAT-6 secretion system (ESS) has remained particularly scarce. The Chinese ST398 isolates exhibited significantly increased expression of ESS genes as compared to predominant hospital-associated clones, which we found is likely due to increased expression of the accessory gene regulator (Agr) system and control of ESS by Agr. Importantly, deletion of essB in ST398 resulted in significantly reduced resistance to neutrophil killing and decreased virulence in murine skin and blood infection models. Our results demonstrate a key function of ESS in promoting virulence and mechanisms of resistance to innate host defense in an important emerging CA-S. aureus lineage. They suggest that ESS has a so far underestimated role in promoting aggressive virulence and epidemiological success of S. aureus. |
| URI | http://hdl.handle.net/20.500.11897/433983 |
| ISSN | 2045-2322 |
| DOI | 10.1038/srep25163 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | å å¦ä¸ å å å·¥ç¨ å¦é ¢ |
