| Title | The platelet derived growth factor-B polymorphism is associated with risk of severe fever with thrombocytopenia syndrome in Chinese individuals |
| Authors | Zhang, Xiao-Ai Guo, Chen-Tao Lu, Qing-Bin Hu, Jian-Gong Cui, Ning Yang, Zhen-Dong Peng, Wei Liu, Rong Hu, Chun-Yan Qin, Shu-Li Wang, Xian-Jun Ding, Shu-Jun Huang, Dou-Dou Liu, Wei Cao, Wu-Chun |
| Affiliation | Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China. Anhui Med Univ, Grad Sch, Hefei 230032, Peoples R China. Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China. Peoples Liberat Army, Hosp 154, Xinyang 464000, Peoples R China. Shangcheng Peoples Hosp, Xinyang 464000, Peoples R China. Shandong Prov Ctr Dis Control & Prevent, Jinan 250001, Peoples R China. Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China. Liu, W (reprint author), Anhui Med Univ, Grad Sch, Hefei 230032, Peoples R China. |
| Keywords | severe fever with thrombocytopenia syndrome polymorphism susceptibility PDGF-B cytokines SYNDROME VIRUS HEMORRHAGIC-FEVER BUNYAVIRUS PATHOGENESIS INFECTION |
| Issue Date | 2016 |
| Publisher | ONCOTARGET |
| Citation | ONCOTARGET.2016,7(22),33340-33349. |
| Abstract | Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus named SFTS virus (SFTSV). We hypothesize that host genetic variations may contribute to susceptibility to SFTS. Results: Compared with the rs1800818 AA genotype, AG + GG genotypes were significantly associated with increased susceptibility to SFTS (odds ratio, 1.66, 95% confidence interval = 1.28-2.16; P < 0.001). By using the ELISA assay, we observed that PDGF-BB concentration was significantly reduced in acute phase of patients than in the controls (P < 0.001) and recovered patients at 6 month (P = 0.007) and 12 month (P = 0.003). A persistently reduced PDGF-BB was also revealed from the SFTSV-infected C57BL/6J mice (P < 0.001). The rs1800818 G allele was associated with decreased serum PDGF-BB levels in SFTS patients at their early infection (P = 0.015). In accordance, the relative mRNA levels of the at-risk G allele of 1800818 were lower than those of the A allele in heterozygous cell from acute phase of SFTS patients. PDGF-B rs1800818 conferred no susceptibility to severe or fatal outcome in SFTS patients. Materials and Methods: An initially small-scale case-control association study guided the selection of platelet derived growth factor-B (PDGF-B) rs1800818 in 1020 SFTS patients and 1353 controls. Functional analyses were conducted to verify the biological significance of rs1800818 polymorphism. Conclusions: Our findings suggest that the PDGF-B rs1800818 polymorphism might play a role in mediating the susceptibility to SFTS. |
| URI | http://hdl.handle.net/20.500.11897/433854 |
| ISSN | 1949-2553 |
| DOI | 10.18632/oncotarget.9043 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 公共卫生学院 |
