| Title | Human papillomavirus DNA positivity and seropositivity in rural Chinese men and women: a population-based cross-sectional study |
| Authors | Liu, Fangfang Deng, Qiuju Zhang, Chanyuan Pan, Yaqi Liu, Ying He, Zhonghu Sun, Min Liu, Mengfei Li, Jingjing Li, Xiang Zhang, Chaoting Hang, Dong Ning, Tao Guo, Chuanhai Liang, Yongmei Xu, Ruiping Zhang, Lixin Cai, Hong Ke, Yang |
| Affiliation | Peking Univ, Canc Hosp & Inst, Genet Lab, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China. Anyang Canc Hosp, Anyang, Henan, Peoples R China. |
| Keywords | RANDOMIZED CONTROLLED-TRIAL PARTICLE VACCINE YOUNG-WOMEN DOUBLE-BLIND RISK-FACTORS HPV DNA INFECTION TYPE-16 ANTIBODIES COHORT |
| Issue Date | 2016 |
| Publisher | SCIENTIFIC REPORTS |
| Citation | SCIENTIFIC REPORTS.2016,6. |
| Abstract | Data on simultaneous analysis of human papillomavirus (HPV) DNA and serology and the correlations within a single general population are limited. Among 1603 men and 2187 women enrolled from rural China, serum antibodies against bacterially derived GST-L1 fusion proteins of HPV were assessed with multiplexed serology and HPV DNA was evaluated with PCR-based sequencing. Few subjects were dually positive to HPV DNA and serum antibodies for any HPV (6.6% of men and 3.1% of women). The proportion of men ever having been infected with any HPV (DNA and/or antibody positive) was higher than that of women (71.0% vs. 65.2%, P < 0.001). Type-specific association was observed for genital HPV infection and HPV seropositivity among women but not among men. A positive correlation between the number of lifetime sexual partners and positivity for oncogenic HPV DNA and/or antibodies was found in men but was absent in women. Among 762 couples, the presence of HPV DNA and/or antibodies in one partner was positively associated with the identical HPV type in the other partner. These findings may reflect a site-specific natural course of HPV infection and further understanding of the epidemiology of HPV. |
| URI | http://hdl.handle.net/20.500.11897/433636 |
| ISSN | 2045-2322 |
| DOI | 10.1038/srep26343 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 北京肿瘤医院 |
