| Title | Independent and Joint Effect of Brachial-Ankle Pulse Wave Velocity and Blood Pressure Control on Incident Stroke in Hypertensive Adults |
| Authors | Song, Yun Xu, Benjamin Xu, Richard Tung, Renee Frank, Eric Tromble, Wayne Fu, Tong Zhang, Weiyi Yu, Tao Zhang, Chunyan Fan, Fangfang Zhang, Yan Li, Jianping Bao, Huihui Cheng, Xiaoshu Qin, Xianhui Tang, Genfu Chen, Yundai Yang, Tianlun Sun, Ningling Li, Xiaoying Zhao, Lianyou Hou, Fan Fan Ge, Junbo Dong, Qiang Wang, Binyan Xu, Xiping Huo, Yong |
| Affiliation | Southern Med Univ, Natl Clin Res Study Ctr Kidney Dis, State Key Lab Organ Failure Res, Renal Div,Nanfang Hosp, Guangzhou, Guangdong, Peoples R China. Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China. River Hill High Sch, Clarksville, MD USA. Renmin Univ, Affiliated High Sch China, Beijing, Peoples R China. Shenzhen Coll Int Educ, Shenzhen, Guangdong, Peoples R China. Anhui Med Univ, Inst Biomed, Hefei, Peoples R China. Nanchang Univ, Affiliated Hosp 2, Dept Cardiol, Nanchang, Jiangxi, Peoples R China. Peoples Liberat Army, Gen Hosp, Dept Cardiol, Beijing, Peoples R China. Peoples Liberat Army, Gen Hosp, Dept Geriatr Cardiol, Beijing, Peoples R China. Cent S Univ, Xiangya Hosp, Dept Cardiol, Changsha, Hunan, Peoples R China. Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China. Fourth Mil Med Univ, Tangdu Hosp, Dept Cardiol, Xian 710032, Peoples R China. Fudan Univ, Dept Cardiol, Shanghai Inst Cardiovasc Dis, Zhongshan Hosp, Shanghai 200433, Peoples R China. Fudan Univ, Huashan Hosp, Dept Neurol, Shanghai 200433, Peoples R China. Southern Med Univ, Natl Clin Res Study Ctr Kidney Dis, State Key Lab Organ Failure Res, Renal Div,Nanfang Hosp, Guangzhou, Guangdong, Peoples R China. Huo, Y (reprint author), Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China. |
| Keywords | antihypertensive drugs China longitudinal studies pulse wave analysis stroke STAGE RENAL-DISEASE ALL-CAUSE MORTALITY ARTERIAL STIFFNESS PROGNOSTIC-SIGNIFICANCE AORTIC STIFFNESS CARDIOVASCULAR EVENTS PRIMARY PREVENTION PREDICTOR INDEX METAANALYSIS |
| Issue Date | 2016 |
| Publisher | HYPERTENSION |
| Citation | HYPERTENSION.2016,68(1),46-+. |
| Abstract | Pulse wave velocity (PWV) has been shown to influence the effects of antihypertensive drugs in the prevention of cardiovascular diseases. Data are limited on whether PWV is an independent predictor of stroke above and beyond hypertension control. This longitudinal analysis examined the independent and joint effect of brachial-ankle PWV (baPWV) with hypertension control on the risk of first stroke. This report included 3310 hypertensive adults, a subset of the China Stroke Primary Prevention Trial (CSPPT) with baseline measurements for baPWV. During a median follow-up of 4.5 years, 111 participants developed first stroke. The risk of stroke was higher among participants with baPWV in the highest quartile than among those in the lower quartiles (6.3% versus 2.4%; hazard ratio, 1.66; 95% confidence interval, 1.06-2.60). Similarly, the participants with inadequate hypertension control had a higher risk of stroke than those with adequate control (5.1% versus 1.8%; hazard ratio, 2.32; 95% confidence interval, 1.49-3.61). When baPWV and hypertension control were examined jointly, participants in the highest baPWV quartile and with inadequate hypertension control had the highest risk of stroke compared with their counterparts (7.5% versus 1.3%; hazard ratio, 3.57; 95% confidence interval, 1.88-6.77). There was a significant and independent effect of high baPWV on stroke as shown among participants with adequate hypertension control (4.2% versus 1.3%; hazard ratio, 2.29, 95% confidence interval, 1.09-4.81). In summary, among hypertensive patients, baPWV and hypertension control were found to independently and jointly affect the risk of first stroke. Participants with high baPWV and inadequate hypertension control had the highest risk of stroke compared with other groups. |
| URI | http://hdl.handle.net/20.500.11897/433618 |
| ISSN | 0194-911X |
| DOI | 10.1161/HYPERTENSIONAHA.115.07023 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第一医院 人民医院 |
