| Title | Altered serum levels of interleukin-3 in first-episode drug-naive and chronic medicated schizophrenia |
| Authors | Yang, FuYin Zhang, Tong Xiu, Mei Hong Tang, Wei Han, Mei Tan, YunLong Chen, Da Chun Chen, Song Tan, Shu Ping Soares, Jair C. Tang, Wen Jie Zhang, Xiang Yang |
| Affiliation | Wenzhou Med Univ, Wenzhou 325000, Zhejiang, Peoples R China. Lucheng Psychiat Hosp, Wenzhou, Zhejiang, Peoples R China. Peking Univ, Beijing HuiLongGuan Hosp, Beijing, Peoples R China. Wenzhou Med Univ, Kangning Hosp, Wenzhou, Zhejiang, Peoples R China. Univ Wollongong, Sch Med, Wollongong, NSW 2522, Australia. Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA. IHMRI, Wollongong, NSW, Australia. Wenzhou Med Univ, Wenzhou 325000, Zhejiang, Peoples R China. Zhang, XY (reprint author), Beijing Hui Long Guan Hosp, Psychiat Res Ctr, Beijing 100096, Peoples R China. |
| Keywords | Schizophrenia Interleukin-3 Cytokines Immune Psychopathology CYTOKINE ALTERATIONS TRANSGENIC MICE NEURONAL DEATH NERVOUS-SYSTEM PSYCHOPATHOLOGY BRAIN PATHOPHYSIOLOGY METAANALYSIS MODEL INFLAMMATION |
| Issue Date | 2016 |
| Publisher | SCHIZOPHRENIA RESEARCH |
| Citation | SCHIZOPHRENIA RESEARCH.2016,176(2-3),196-200. |
| Abstract | Elevated serumlevels of Interleukin-3 (IL-3), a major component of the cytokines, have been observed in chronic and medicated patients with schizophrenia, but this elevation may reflect either or both medication and illness chronicity effects. Thus, we compared serum IL-3 levels in first-episode drug-naive (FEDN) to chronic medicated patients with schizophrenia and examined the association of IL-3 with their psychopathological symptoms. Serum IL-3 levels were assessed in 55 FEDN patients, 52 chronic medicated patients and 43 healthy controls. Schizophrenia symptomatology was assessed with the Positive and Negative Syndrome Scale (PANSS). Serum IL-3 levels were measured by sandwich enzyme-linked immunosorbent assay (ELISA). We found significantly lower IL-3 levels in FEDN patients than both chronic patients and healthy controls (both p < 0.001), while IL-3 levels in chronic patientsweremarkedly higher than in healthy controls. No significant association was observed between IL-3 and any clinical psychopathology in FEDN patients; however, we found a significant correlation between serum IL-3 levels and the PANSS general psychopathology subscore in chronic medicated patients (p < 0.05). Decreased IL-3 levels in FEDN patients suggest that suppressed immune function may be associated with developing schizophrenia, but as the disease progresses IL-3 levels increase perhaps related to medication treatment or other factors that occur during chronic illness. (C) 2016 Elsevier B.V. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/433553 |
| ISSN | 0920-9964 |
| DOI | 10.1016/j.schres.2016.05.010 |
| Indexed | SCI(E) PubMed SSCI |
| Appears in Collections: | 北京回龙观医院 |
