| Title | Light-Induced Hydrogel Based on Tumor-Targeting Mesoporous Silica Nanoparticles as a Theranostic Platform for Sustained Cancer Treatment |
| Authors | Chen, Xin Liu, Zhongning Parker, Stephen G. Zhang, Xiaojin Gooding, J. Justin Ru, Yanyan Liu, Yuhong Zhou, Yongsheng |
| Affiliation | Xi An Jiao Tong Univ, Sch Chem Engn & Technol, Inst Polymer Sci Chem Engn, Shanxi Key Lab Energy Chem Proc Intensificat, Xian 710049, Peoples R China. Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing Key Lab Digital Stomatol,Natl Engn Lab Di, Beijing 100081, Peoples R China. Univ New S Wales, Australian Ctr NanoMed, Sch Chem, Sydney, NSW 2052, Australia. Univ New S Wales, ARC Ctr Excellence Convergent Bionano Sci & Techn, Sydney, NSW 2052, Australia. Wuhan Univ, Dept Chem, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China. Xi An Jiao Tong Univ, Sch Chem Engn & Technol, Inst Polymer Sci Chem Engn, Shanxi Key Lab Energy Chem Proc Intensificat, Xian 710049, Peoples R China. Zhou, YS (reprint author), Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing Key Lab Digital Stomatol,Natl Engn Lab Di, Beijing 100081, Peoples R China. Zhang, XJ (reprint author), Wuhan Univ, Dept Chem, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China. |
| Keywords | light responsiveness hydrogel-nanoparticles transformation mesoporous silica nanocarriers biodegradable platform sustained cancer treatment CONTROLLED-RELEASE DRUG-DELIVERY ALPHA-CYCLODEXTRIN GUEST MOLECULES HYALURONIC-ACID IN-VIVO CELLS COMBINATION AZOBENZENE RESISTANCE |
| Issue Date | 2016 |
| Publisher | ACS APPLIED MATERIALS & INTERFACES |
| Citation | ACS APPLIED MATERIALS & INTERFACES.2016,8(25),15857-15863. |
| Abstract | Herein, we report a facile fabrication of a polymer (azobenzene and alpha-cyclodextrin-functionalized hyaluronic acid) and gold nanobipyramids (AuNBs) conjugated mesoporous silica nano particles (MSNs) to be used as an injectable drug delivery system for sustained cancer treatment. Because of the specific affinity between the hyaluronic acid (HA) on MSNs and the CD44 antigen overexpressed on tumor cells, the MSNs can selectively attach to tumor cells. The nanocomposite material then exploits thermoresponsive interactions between alpha-cyclodextrin and azobenzene, and the photothermal properties of gold nanobipyramids, to in situ self-assemble into a hydrogel under near-infrared (NIR) radiation. Upon gelation, the drug (doxorubicin)-loaded MSNs carriers were enclosed in the HA network of the hydrogel, whereas further degradation of the HA in the hydrogel due to the upregulation of hyaluronidase (HAase) around the tumor tissue will result in the release of MSNs from the hydrogel, which can then be taken by tumor cells and deliver their drug to the cell nuclei. This design is able to provide a microenvironment with rich anticancer drugs in, and around, the tumor tissue for time periods long enough to prevent the recrudescence of the disease. The extra efficacy that this strategy affords builds upon the capabilities of conventional therapies. |
| URI | http://hdl.handle.net/20.500.11897/433452 |
| ISSN | 1944-8244 |
| DOI | 10.1021/acsami.6b02562 |
| Indexed | SCI(E) EI PubMed |
| Appears in Collections: | 口腔医院 |
