| Title | Clinicopathologic and Molecular Features of Colorectal Adenocarcinoma with Signet-Ring Cell Component |
| Authors | Wei, Qing Wang, Xicheng Gao, Jing Li, Jian Li, Jie Qi, Changsong Li, Yanyan Li, Zhongwu Shen, Lin |
| Affiliation | Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Dept Gastrointestinal Oncol,Minist Educ, Beijing 100871, Peoples R China. Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Dept Pathol,Minist Educ, Beijing 100871, Peoples R China. Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Dept Gastrointestinal Oncol,Minist Educ, Beijing 100871, Peoples R China. Li, ZW (reprint author), Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Dept Pathol,Minist Educ, Beijing 100871, Peoples R China. |
| Keywords | MUCINOUS ADENOCARCINOMA COLON-CANCER CARCINOMA SURVIVAL MUTATION RECTUM SUSCEPTIBILITY POLYPOSIS VARIANTS CARRIERS |
| Issue Date | 2016 |
| Publisher | PLOS ONE |
| Citation | PLOS ONE.2016,11(6). |
| Abstract | Background We performed a retrospective study to assess the clinicopathological characters, molecular alterations and multigene mutation profiles in colorectal cancer patients with signet-ring cell component. Methods Between November 2008 and January 2015, 61 consecutive primary colorectal carcinomas with signet-ring cell component were available for pathological confirmation. RAS/BRAF status was performed by direct sequencing. 14 genes associated with hereditary cancer syndromes were analyzed by targeted gene sequencing. Results A slight male predominance was detected in these patients (59.0%). Colorectal carcinomas with signet-ring cell component were well distributed along the large intestine. A frequently higher TNM stage at the time of diagnosis was observed, compared with the conventional adenocarcinoma. Family history of malignant tumor was remarkable with 49.2% in 61 cases. The median OS time of stage IV patients in our study was 14 months. RAS mutations were detected in 22.2% (12/54) cases with KRAS mutations in 16.7% (9/54) cases and Nras mutations in 5.4%(3/54) cases. BRAF V600E mutation was detected in 3.7% (2/54) cases. As an exploration, we analyzed 14 genes by targeted gene sequencing. These genes were selected based on their biological role in association with hereditary cancer syndromes. 79.6% cases carried at least one pathogenic mutation. Finally, the patients were classified by the percentage of signet-ring cell. 39 (63.9%) cases were composed of >= 50% signet-ring cells; 22 (36.1%) cases were composed of <50% signet-ring cells. Wecompared clinical parameters, molecular and genetic alterations between the two groups and found no significant differences. Conclusions Colorectal adenocarcinoma with signet-ring cell component is characterized by advanced stage at diagnosis with remarkable family history of malignant tumor. It is likely a negative prognostic factor and tends to affect male patients with low rates of RAS/BRAF mutation. Colorectal patients with any component of signet-ring cells, regardless of the extent, shared similar clinicopathological characteristics, molecular alterations and genetic profiles. |
| URI | http://hdl.handle.net/20.500.11897/433348 |
| ISSN | 1932-6203 |
| DOI | 10.1371/journal.pone.0156659 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 北京肿瘤医院 |
