| Title | Allogeneic stem cell transplant may improve the outcome of adult patients with inv(16) acute myeloid leukemia in first complete remission with poor molecular responses to chemotherapy |
| Authors | Qin, Ya-Zhen Xu, Lan-Ping Chen, Huan Jiang, Qian Wang, Yu Jiang, Hao Zhang, Xiao-Hui Han, Wei Chen, Yu-Hong Wang, Feng-Rong Wang, Jing-Zhi Zhu, Hong-Hu Liu, Yan-Rong Jiang, Bin Liu, Kai-Yan Huang, Xiao-Jun |
| Affiliation | Peking Univ, Inst Hematol, Peking Univ Peoples Hosp, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China. Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China. Peking Univ, Inst Hematol, Peking Univ Peoples Hosp, Xizhimen South St 11, Beijing 100044, Peoples R China. |
| Keywords | Clinical results myeloid leukemias and dysplasias prognostication MINIMAL RESIDUAL DISEASE POLYMERASE-CHAIN-REACTION FRENCH AML INTERGROUP QUANTITATIVE RT-PCR C-KIT MUTATIONS RISK STRATIFICATION PROGNOSTIC VALUE MARROW-TRANSPLANTATION CANCER PROGRAM GROUP-B |
| Issue Date | 2015 |
| Publisher | LEUKEMIA & LYMPHOMA |
| Citation | LEUKEMIA & LYMPHOMA.2015,56,(11),3116-3123. |
| Abstract | Eighty-six adult patients with inv(16) acute myeloid leukemia (AML) in first complete remission (CR1) were serially monitored for CBFB-MYH11 transcript levels during the early courses of chemotherapy. Fifty-seven and 29 of them received chemotherapy/autologous stem cell transplant (SCT) and allogeneic (allo-)SCT after second consolidation, respectively. For patients receiving chemotherapy/autologous SCT, the sole independent adverse prognostic factor for the cumulative incidence of relapse (CIR), disease-free survival (DFS) and overall survival (OS) was a CBFB-MYH11 level > 0.2% after course 2 consolidation (p = 0.003, 0.003 and 0.031), which was used to define a poor molecular response (MR). Allo-SCT significantly decreased the 3-year CIR and increased the DFS and OS of patients with a poor MR (p < 0.0001, 0.0001 and 0.045) but did not improve the outcome of patients with good MR (all p > 0.05) compared with chemotherapy/autologous SCT. Therefore, allo-SCT could improve the outcome of adult patients with inv(16) AML in CR1 with a poor MR during the early courses of chemotherapy. |
| URI | http://hdl.handle.net/20.500.11897/420132 |
| ISSN | 1042-8194 |
| DOI | 10.3109/10428194.2015.1032964 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 人民医院 |
