| Title | Elevated ZNF703 Protein Expression Is an Independent Unfavorable Prognostic Factor for Survival of the Patients with Head and Neck Squamous Cell Carcinoma |
| Authors | Yang, Hang Jiang, Wen-Qi Cao, Ye Sun, Yong-An Wei, Jing An, Xin Zhang, Ying-Chun Song, Ming Wang, Shu-Sen Yuan, Zhong-Yu Peng, Rou-Jun Chen, Tan-Huan Li, Li-Ren Shi, Yan-Xia |
| Affiliation | Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China. Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510060, Guangdong, Peoples R China. Sun Yat Sen Univ, Ctr Canc, Clin Trial Ctr, Guangzhou 510060, Guangdong, Peoples R China. Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China. Guangxi Tradit Chinese Med Univ, Ruikang Hosp, Dept Med Oncol, Nanning 530011, Peoples R China. Sun Yat Sen Univ, Ctr Canc, Dept Pathol, Guangzhou 510060, Guangdong, Peoples R China. Sun Yat Sen Univ, Ctr Canc, Dept Head & Neck Surg, Guangzhou 510060, Guangdong, Peoples R China. Huizhou Municipal Cent Hosp, Dept Oncol, Huizhou 516001, Peoples R China. Sun Yat Sen Univ, Ctr Canc, Dept Colorectal Surg, Guangzhou 510060, Guangdong, Peoples R China. |
| Keywords | CHROMOSOME ARM 8P BREAST-CANCER PROGRESSION STATISTICS ONCOGENES AMPLICON FAMILY GENES |
| Issue Date | 2015 |
| Publisher | DISEASE MARKERS |
| Citation | DISEASE MARKERS.2015. |
| Abstract | Aim. Data from The Cancer Genome Atlas (TCGA) show that the ZNF703 gene amplifies and overexpresses in head and neck squamous cell carcinomas (HNSCC). However, the clinical relevance of this observation in HNSCC is unclear. The purpose of this study was to clarify the expression of ZNF703 protein and its prognostic effect on HNSCC. Methods. Two hundred ten HNSCC patients from Sun Yat-Sen University Cancer Center with complete survival follow-up were included in this study. Tumor samples from primary sites were collected. The expression of the ZNF703 protein was tested by immunohistochemistry (IHC). Results. The high expression of ZNF703 in HNSCC tumor tissues was significantly higher than that of the matched noncancerous tissues (48.6% versus 11.6%, P < 0.001). ZNF703 overexpression was correlated with tumor position (laryngeal carcinoma) and recurrence (all P < 0.05). Multivariate analysis revealed that ZNF703 protein overexpression was an independent prognostic factor (P = 0.022, hazard ratio = 1.635, 95% CI 1.073-2.493) in HNSCC patients. Conclusion. ZNF703 overexpression is associated with adverse prognosis in HNSCC, which might be a novel biomarker of HNSCC. |
| URI | http://hdl.handle.net/20.500.11897/419373 |
| ISSN | 0278-0240 |
| DOI | 10.1155/2015/640263 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第一医院 |
