| Title | Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study |
| Authors | Guo, Ming-ming Duan, Xue-ning Cui, Shu-de Tian, Fu-guo Cao, Xu-chen Geng, Cui-zhi Fan, Zhi-min Wang, Xiang Wang, Shu Jiang, Hong-chuan Zhang, Jian-guo Jin, Feng Tang, Jin-hai Liang, Hong Yang, Zhen-lin Wang, Hai-bo Wang, Qi-tang Li, Guo-lou Li, Liang Zhu, Shi-guang Zuo, Wen-shu Liu, Li-yuan Wang, Lu Ma, Dan-dan Liu, Shu-chen Xiang, Yu-juan Liu, Lu Ye, Chun-miao Zhou, Wen-zhong Wang, Fei Yu, Li-xiang Ma, Zhong-bing Yu, Zhi-gang |
| Affiliation | Shandong Univ, Sch Med, Jinan 250100, Shandong, Peoples R China. Shandong Univ, Hosp 2, Dept Breast Surg, Jinan 250100, Shandong, Peoples R China. Peking Univ, Hosp 1, Breast Dis Ctr, Beijing 100871, Peoples R China. Zhengzhou Univ, Affiliated Tumor Hosp, Dept Breast Surg, Zhengzhou 450052, Henan, Peoples R China. Shanxi Canc Hosp, Dept Breast Surg, Taiyuan, Shanxi, Peoples R China. Tianjin Med Univ, Canc Inst & Hosp, Natl Clin Res Ctr Canc, Tianjin, Peoples R China. Hebei Med Univ, Hosp 4, Breast Ctr, Shijiazhuang, Hebei, Peoples R China. Jilin Univ, Hosp 1, Dept Breast Surg, Changchun 130023, Jilin, Peoples R China. Chinese Acad Med Sci, Canc Hosp, Dept Breast Surg, Beijing 100730, Peoples R China. Peking Univ, Peoples Hosp, Breast Dis Ctr, Beijing 100871, Peoples R China. Beijing Chaoyang Hosp, Dept Gen Surg, Beijing, Peoples R China. Harbin Med Univ, Affiliated Hosp 2, Dept Gen Surg, Harbin, Heilongjiang, Peoples R China. China Med Univ, Affiliated Hosp 1, Dept Breast Surg, Shenyang 110001, Liaoning, Peoples R China. Nanjing Med Univ, Affiliated Canc Hosp, Canc Inst Jiangsu Prov, Dept Gen Surg, Nanjing, Jiangsu, Peoples R China. Linyi Peoples Hosp, Dept Gen Surg, Linyi, Shandong, Peoples R China. Binzhou Med Univ, Affiliated Hosp 1, Dept Thyroid & Breast Surg, Binzhou, Shandong, Peoples R China. Qingdao Univ, Affiliated Hosp, Breast Ctr, Qingdao 266071, Shandong, Peoples R China. Qingdao Cent Hosp, Qingdao Med Coll, Affiliated Hosp 2, Dept Breast Surg, Qingdao, Shandong, Peoples R China. Weifang Tradit Chinese Hosp, Dept Breast & Thyroid Surg, Weifang, Shandong, Peoples R China. Zibo Cent Hosp, Dept Breast & Thyroid Surg, Zibo, Shandong, Peoples R China. Yantai Yuhuangding Hosp, Dept Breast Surg, Yantai, Shandong, Peoples R China. Shandong Canc Hosp, Breast Canc Ctr, Jinan, Shandong, Peoples R China. Shandong Univ, Sch Publ Hlth, Inst Epidemiol, Jinan 250100, Shandong, Peoples R China. Shandong Univ, Sch Publ Hlth, Div Epidemiol & Biostat, Jinan 250100, Shandong, Peoples R China. |
| Keywords | METAANALYSIS RECEPTORS COMPLEX PROTEIN WOMEN |
| Issue Date | 2015 |
| Publisher | PLOS ONE |
| Citation | PLOS ONE.2015,10,(6). |
| Abstract | The level of total adiponectin, a mixture of different adiponectin forms, has been reported associated with breast cancer risk with inconsistent results. Whether the different forms play different roles in breast cancer risk prediction is unclear. To examine this, we measured total and high molecular weight (HMW) adiponectin in a case-control study (1167 sets). Higher circulating HMW adiponectin was negatively associated with breast cancer risk after adjusting for menopausal status and family history of breast cancer (P=0.024). We analyzed the relationship between adiponectin and breast cancer risk in 6 subgroups. Higher circulating HMW adiponectin was also negatively associated with breast cancer risk (P=0.020, 0.014, 0.035) in the subgroups of postmenopausal women, negative family history of breast cancer, BMI>=24.0. Total adiponectin was positively associated with breast cancer (P=0.028) in the subgroup of BMI<=24.0. Higher HMW/total adiponectin ratio was negatively associated with breast cancer (P=0.019) in the subgroup of postmenopausal women. Interestingly, in the subgroup of women with family history of breast cancer, higher circulating total and HMW adiponectin were positively associated with breast cancer risk (P=0.034, 0.0116). This study showed different forms of circulating adiponectin levels might play different roles in breast cancer risk. A higher circulating HMW adiponectin is associated with a decreased breast cancer risk, especially in postmenopausal, without family history of breast cancer or BMI>=24.0 subgroups, whereas higher circulating HMW adiponectin levels is a risk factor in women with a family history of breast cancer. Further investigation of different forms of adiponectin on breast cancer risk is needed. |
| URI | http://hdl.handle.net/20.500.11897/419319 |
| ISSN | 1932-6203 |
| DOI | 10.1371/journal.pone.0129246 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第一医院 人民医院 |
