| Title | Ambient particulate air pollution and circulating antioxidant enzymes: A repeated-measure study in healthy adults in Beijing, China |
| Authors | Wu, Shaowei Wang, Bin Yang, Di Wei, Hongying Li, Hongyu Pan, Lu Huang, Jing Wang, Xin Qin, Yu Zheng, Chanjuan Shima, Masayuki Deng, Furong Guo, Xinbiao |
| Affiliation | Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China. Peking Univ, Sch Publ Hlth, Inst Reprod & Child Hlth, Beijing 100191, Peoples R China. Hyogo Coll Med, Dept Publ Hlth, Nishinomiya, Hyogo, Japan. Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, 38 Xueyuan Rd, Beijing 100191, Peoples R China. |
| Keywords | Air pollution Antioxidant enzyme Chemical constituent Particulate matter HEART-RATE-VARIABILITY EPITHELIAL LUNG-CELLS OXIDATIVE STRESS TRANSITION-METALS YOUNG-ADULTS CHEMICAL-CONSTITUENTS URBAN AIR IN-VITRO EXPOSURE MATTER |
| Issue Date | 2016 |
| Publisher | ENVIRONMENTAL POLLUTION |
| Citation | ENVIRONMENTAL POLLUTION.2016,208,(,SI),16-24. |
| Abstract | The association of systemic antioxidant activity with ambient air pollution has been unclear. A panel of 40 healthy college students underwent repeated blood collection for 12 occasions under three exposure scenarios before and after relocating from a suburban area to an urban area in Beijing, China in 2010-2011. We measured various air pollutants including fine particles (PM2.5) and determined circulating levels of antioxidant enzymes extracellular superoxide dismutase (EC-SOD) and glutathione peroxidase 1 (GPX1) in the laboratory. An interquartile range increase of 63.4 mu g/m(3) at 3-d PM2.5 moving average was associated with a 6.3% (95% CI: 0.6, 12.4) increase in EC-SOD and a 5.5% (95% CI: 1.3, 9.8) increase in GPX1. Several PM2.5 chemical constituents, including negative ions (nitrate and chloride) and metals (e.g., iron and strontium), were consistently associated with increases in EC-SOD and GPX1. Our results support activation of circulating antioxidant enzymes following exposure to particulate air pollution. (C) 2015 Elsevier Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/419282 |
| ISSN | 0269-7491 |
| DOI | 10.1016/j.envpol.2015.06.002 |
| Indexed | SCI(E) EI PubMed |
| Appears in Collections: | 公共卫生学院 |
