| Title | A review of the burden of hepatitis C virus infection in China, Japan, South Korea and Taiwan |
| Authors | Bennett, Heather Waser, Nathalie Johnston, Karissa Kao, Jia-Horng Lim, Young-Suk Duan, Zhong-Ping Lee, Youn-Jae Wei, Lai Chen, Chien-Jen Sievert, William Yuan, Yong Li, Hong |
| Affiliation | ICON Plc, ICON Epidemiol, Toronto, ON, Canada. ICON Plc, ICON Epidemiol, Vancouver, BC, Canada. Natl Taiwan Univ, Coll Med, Dept Internal Med, Natl Taiwan Univ Hosp, Taipei, Taiwan. Natl Taiwan Univ Hosp, Hepatitis Res Ctr, Taipei, Taiwan. Asan Med Ctr, Dept Gastroenterol, Seoul, South Korea. Beijing Capital Med Univ, Yon An Hosp, Beijing, Peoples R China. Inje Univ, Coll Med, Busan Paik Hosp, Dept Internal Med, Busan, South Korea. Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100871, Peoples R China. Natl Taiwan Univ, Acad Siica, Taipei 10764, Taiwan. Monash Univ, Monash Hlth, Melbourne, Vic 3004, Australia. Bristol Myers Squibb Co, Princeton, NJ USA. |
| Keywords | Hepatitis C virus Epidemiology Prevalence Incidence Genotype Complications of HCV infection METHADONE-MAINTENANCE TREATMENT VIRAL-HEPATITIS PREVALENCE EPIDEMIOLOGY AREA HIV COINFECTIONS POPULATION SHANGHAI PROVINCE |
| Issue Date | 2015 |
| Publisher | HEPATOLOGY INTERNATIONAL |
| Citation | HEPATOLOGY INTERNATIONAL.2015,9,(3),378-390. |
| Abstract | Hepatitis C virus (HCV) infection is associated with substantial clinical and economic burden and is an important public health issue in Asia. The objective of this review was to characterize HCV epidemiology and related complications in China, Japan, South Korea and Taiwan. A search of electronic databases and conference abstracts identified 71 potentially relevant articles. Of those, 55 were included in the epidemiology review and 9 in the review of HCV-related complications. HCV prevalence in the general population was 1.6 % in China, 0.6-0.9 % in Japan, 0.6-1.1 % in South Korea and 1.8-5.5 % in Taiwan. Prevalence was higher for injecting drug users (48-90 %) and those with human immunodeficiency virus coinfection (32-85 %) and was lower for blood donors (< 1 %). Annual incidence of HCV in China was 6.01 per 100,000. HCV genotype 1b was associated with the highest incidence of hepatocellular carcinoma (HCC). Five-year survival for patients with liver cirrhosis was 73.8 %, decreasing to 39.2 % following liver transplantation; the majority of deaths were attributable to HCC. Limitations were that the majority of studies included in the epidemiology review were small, regional studies conducted in specific populations, and there was an absence of large population-based studies. Thus, estimates may not be representative of the epidemiology of HCV for each country. The prevalence HCV in China and HCV incidence in the Asian region remain largely unknown, and they are likely underestimated. Further epidemiologic and clinical data are needed to provide more precise estimates for use by public health agencies. |
| URI | http://hdl.handle.net/20.500.11897/418929 |
| ISSN | 1936-0533 |
| DOI | 10.1007/s12072-015-9629-x |
| Indexed | SCI(E) |
| Appears in Collections: | 人民医院 |
