| Title | Circulating PD-L1 in NSCLC patients and the correlation between the level of PD-L1 expression and the clinical characteristics |
| Authors | Zhang, Jie Gao, Jing Li, Yanyan Nie, Jun Dai, Ling Hu, Weiheng Chen, Xiaoling Han, Jindi Ma, Xiangjuan Tian, Guangming Wu, Di Shen, Lin Fang, Jian |
| Affiliation | Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Thorac Oncol & GI Oncol 2, Beijing 100142, Peoples R China. Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept GI Oncol, Beijing 100142, Peoples R China. |
| Keywords | Enzyme-linked immunosorbent assay (ELISA) immunotherapy lung cancer PD-L1 CELL LUNG-CANCER ANTI-PD-L1 ANTIBODY LIGAND-1 EXPRESSION OVEREXPRESSION MUTATIONS |
| Issue Date | 2015 |
| Publisher | THORACIC CANCER |
| Citation | THORACIC CANCER.2015,6,(4),534-538. |
| Abstract | BackgroundThe programmed cell death-1/programmed cell death-1 ligand (PD-1/PD-L1) pathway plays a crucial role in tumor evasion. This study evaluated the association between circulating PD-L1 expression and clinical characteristics in patients with advanced non-small cell lung cancer (NSCLC). MethodsA total of 109 advanced NSCLC and 65 healthy patients from the Beijng Cancer Hospital were enrolled in the study. Circulating PD-L1 expression was tested by enzyme-linked immunosorbent assay. The associations between the level of PD-L1 expression and clinicopathologic features and prognosis were statistically analyzed. ResultsThe expression of PD-L1 in advanced NSCLC patients was significantly upregulated compared with the healthy control (P < 0.001). The expression of PD-L1 was significantly correlated with abdominal organ metastasis (P = 0.004). A high PD-L1 expression had a worse prognosis than a low expression in patients (18.7 vs. 26.8 month, P < 0.001). ConclusionsPD-L1 was elevated in advanced NSCLC patients and may play an important role in tumor immune evasion and patient prognosis. |
| URI | http://hdl.handle.net/20.500.11897/418427 |
| ISSN | 1759-7706 |
| DOI | 10.1111/1759-7714.12247 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 北京肿瘤医院 |
