| Title | Mix-breeding with HEV-infected swine induced inapparent HEV infection in SPF rabbits |
| Authors | Liu, Lin Wang, Lin Xia, Junke Zhang, Yulin Zeng, Hang Liu, Peng Zou, Qinghua Wang, Ling Zhuang, Hui |
| Affiliation | Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Microbiol, 38 Xueyuan Rd, Beijing 100191, Peoples R China. Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Ctr Infect Dis, Beijing 100191, Peoples R China. |
| Keywords | hepatitis E virus cross-species transmission zoonosis swine rabbit HEPATITIS-E VIRUS CROSS-SPECIES INFECTION UNITED-STATES SEROLOGICAL EVIDENCE EMERGING INFECTION DOMESTIC-ANIMALS FARMED RABBITS GENOTYPES 1 CHINA TRANSMISSION |
| Issue Date | 2016 |
| Publisher | JOURNAL OF MEDICAL VIROLOGY |
| Citation | JOURNAL OF MEDICAL VIROLOGY.2016,88,(4),681-685. |
| Abstract | Studies have shown that swine HEV (sHEV) and rabbit HEV (rHEV) can experimentally infect rabbits and swine, respectively. However, no published data have documented isolating sHEV strains from rabbits in natural environment so far. To clarify the possibility of natural cross-species transmission of sHEV to rabbits, the pigs with HEV infection were farmed along with SPF rabbits in the same enclosed space. Five of 10 rabbits had seroconversion for anti-HEV antibody from the third week after mix-breeding. However, HEV RNA remained undetectable in feces, serum, liver and bile of the ten rabbits; and no obvious elevation of ALT was observed. The results possibly suggested that sHEV might lead to an inapparent infection of SPF rabbits by fecal-oral route. J. Med. Virol. 88:681-685, 2016. (c) 2015 Wiley Periodicals, Inc. |
| URI | http://hdl.handle.net/20.500.11897/418211 |
| ISSN | 0146-6615 |
| DOI | 10.1002/jmv.24374 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 基础医学院 |
