| Title | Naturally occurring hepatitis C virus protease inhibitors resistance-associated mutations among chronic hepatitis C genotype 1b patients with or without HIV co-infection |
| Authors | Cao, Ying Zhang, Yu Bao, Yi Zhang, Renwen Zhang, Xiaxia Xia, Wei Wu, Hao Xu, Xiaoyuan |
| Affiliation | Peking Univ, Hlth Sci Ctr, Hosp 1, Dept Infect Dis, Beijing, Peoples R China. Capital Med Univ, Beijing Youan Hosp, Dept Infect Dis, Beijing, Peoples R China. Shiyan Taihe Hosp, Dept Neurol, Shiyan, Peoples R China. Peking Univ, Hosp 1, Dept Infect Dis, 8 Xishiku St, Beijing 100034, Peoples R China. |
| Keywords | hepatitis C virus HIV/hepatitis C virus co-infection non-structural 3 protease inhibitor resistance mutation TREATMENT-NAIVE PATIENTS INTERFERON-ALPHA 2A ANTIVIRAL RESISTANCE PLUS RIBAVIRIN PHASE-3 TRIAL DOUBLE-BLIND INFECTION SIMEPREVIR THERAPY CHINA |
| Issue Date | 2016 |
| Publisher | HEPATOLOGY RESEARCH |
| Citation | HEPATOLOGY RESEARCH.2016,46(6),552-558. |
| Abstract | The aim of this study was to measure the frequency of natural mutations in hepatitis C virus (HCV) mono-infected and HIV/HCV co-infected protease inhibitor (PI)-naive patients. Methods: Population sequence of the non-structural (NS) 3 protease gene was evaluated in 90 HCV mono-infected and 96 HIV/HCV co-infected PI treatment-naive patients. The natural prevalence of PI resistance mutations in both groups was compared. Results: Complete HCV genotype 1b NS3 sequence information was obtained for 152 (81.72%) samples. Seven sequences (8.33%) of the 84 HCV mono-infected patients and 21 sequences (30.88%) of the 68 HIV/HCV co-infected patients showed amino acid substitutions associated with HCV PI resistance. There was a significant difference in the natural prevalence of PI resistance mutations between these two groups (P = 0.000). The mutations T54S, R117H and N174F were observed in 1.19%, 5.95% and 1.19% of HCV mono-infected patients. The mutations F43S, T54S, Q80K/R, R155K, A156G/V, D168A/E/G and V170A were found in 1.47%, 4.41%, 1.47%/1.47%, 2.94%, 23.53%/1.47%, 1.47%/1.47%/1.47% and 1.47% of HIV/HCV co-infected patients, respectively. In addition, the combination mutations in the NS3 region were detected only in HIV/HCV genotype 1b co-infected patients. Conclusion: Naturally occurring HCV PI resistance mutations existed in HCV mono-infected and HIV/HCV co-infected genotype 1b PI-naive patients. HIV co-infection was associated with a greater frequency of PI resistance mutations. The impact of HIV infection on baseline HCV PI resistance mutations and treatment outcome in chronic hepatitis C (CHC) patients should be further analyzed. |
| URI | http://hdl.handle.net/20.500.11897/418145 |
| ISSN | 1386-6346 |
| DOI | 10.1111/hepr.12590 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第一医院 |
