| Title | Effect of follicle-stimulating hormone receptor Asn680Ser polymorphism on the outcomes of controlled ovarian hyperstimulation: an updated meta-analysis of 16 cohort studies |
| Authors | Tang, Huilin Yan, Yingying Wang, Tiansheng Zhang, Ting Shi, Weilong Fan, Rong Yao, Yao Zhai, Suodi |
| Affiliation | Peking Univ, Hosp 3, Dept Pharm, Beijing 100191, Peoples R China. Peking Univ, Hlth Sci Ctr, Dept Pharm Adm & Clin Pharm, Sch Pharmaceut Sci, Beijing 100191, Peoples R China. Third Mil Med Univ, Xinqiao Hosp, Dept Pharm, Chongqing 400037, Peoples R China. |
| Keywords | FSHR Genetic polymorphism Ovarian response Meta-analysis IN-VITRO FERTILIZATION FSH-RECEPTOR SER680ASN POLYMORPHISM GENE POLYMORPHISMS RESERVE MARKERS GENOTYPE IVF PHARMACOGENETICS RESPONSIVENESS EFFICACY |
| Issue Date | 2015 |
| Publisher | JOURNAL OF ASSISTED REPRODUCTION AND GENETICS |
| Citation | JOURNAL OF ASSISTED REPRODUCTION AND GENETICS.2015,32,(12),1801-1810. |
| Abstract | The purpose of this study is to evaluate the influence of follicle-stimulating hormone receptor (FSHR) Asn680Ser polymorphism on the ovarian response to exogenous follicle-stimulating hormone (FSH) and clinical outcomes in women undergoing controlled ovarian hyperstimulation (COH). A database search was conducted to identify the eligible studies that investigated the effect of FSHR Asn680Ser polymorphism on ovarian response and clinical outcomes. A pooled analysis was performed with the odds ratio (OR) or weighted mean difference (WMD) and their respective 95 % confidence interval (CI) by the STATA software with random effects model. Sixteen cohort studies comprising a total of 4287 subjects were included. The number of retrieved oocytes was significantly fewer in subjects with the SS genotype at position 680, compared to subjects with the NN or NS genotype (WMD = -1.36, 95 % CI = -1.85 to -0.87). Lack of association was detected between the genotypes (SS genotype vs. NN or NS genotype) and clinical outcomes such as exogenous FSH dose (WMD = 98.96 IU, 95 % CI = -22.33 to 220.24), poor response (OR = 1.08, 95 % CI = 0.71-1.64), ovarian hyperstimulation syndrome (OHSS) (OR = 1.58, 95 % CI = 0.41-6.07), and clinical pregnancy rate (OR = 1.10, 95 % CI = 0.86-1.40). However, poor ovarian response and number of retrieved oocytes were significantly influenced by the Asn680Ser polymorphism in the Asian subjects. In addition, no publication bias was detected. FSHR Asn680Ser polymorphism might be a significant biomarker for predicting the number of retrieved oocytes and poor response, especially in Asian subjects. Other outcomes such as exogenous FSH dose, OHSS, and pregnancy rate were not influenced by FSHR Asn680Ser polymorphism. |
| URI | http://hdl.handle.net/20.500.11897/417350 |
| ISSN | 1058-0468 |
| DOI | 10.1007/s10815-015-0600-5 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第三医院 |
