| Title | CMTM8 inhibits the carcinogenesis and progression of bladder cancer |
| Authors | Gao, Denghui Hu, Hao Wang, Ying Yu, Weidong Zhou, Jianhua Wang, Xiaofeng Wang, Weiping Zhou, Chunyan Xu, Kexin |
| Affiliation | Peking Univ, Peoples Hosp, Dept Urol, Beijing 100871, Peoples R China. Sch Basic Med Sci, Dept Immunol, Beijing, Peoples R China. Peking Univ, Minist Hlth, Key Lab Med Immunol, Beijing 100871, Peoples R China. Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing, Peoples R China. Peking Univ, Minist Educ China, Key Lab Mol Cardiovasc Sci, Beijing 100871, Peoples R China. Peking Univ, Peoples Hosp, Dept Urol, 11 Xizhimen St, Beijing 100871, Peoples R China. |
| Keywords | bladder cancer CMTM8 proliferation invasion migration EPIDERMAL-GROWTH-FACTOR UROTHELIAL CARCINOMA TUMOR-SUPPRESSOR CELL CARCINOMA EXPRESSION STATISTICS RECEPTORS APOPTOSIS INVASION CLONING |
| Issue Date | 2015 |
| Publisher | ONCOLOGY REPORTS |
| Citation | ONCOLOGY REPORTS.2015,34,(6),2853-2863. |
| Abstract | Bladder cancer is the most common tumor of the urinary tract. The incidence of bladder cancer has increased in the last few decades, thus novel molecular markers for early diagnosis and more efficacious treatment are urgently needed. Chemokine-like factor (CKLF)-like MARVEL transmembrane domain containing 8 (CMTM8) is downregulated in several types of cancers and is associated with tumor progression. However, CMTM8 expression has been unexplored in bladder cancer to date. Our results revealed that the expression of CMTM8 was negative in 46 of 74 (62.2%) bladder cancer samples via immunohistochemistry assay. CMTM8 downregulation was associated with advancing tumor stage and tumor grade. CMTM8 was successfully overexpressed by lentivirus in EJ and T24 cells, and the CCK-8 and Transwell assays showed that CMTM8 overexpression decreased cell proliferation, migration and invasion in vitro. In tumor xenografts upregulation of CMTM8 inhibited tumor growth and lymph node metastasis in vivo. In conclusion, overexpression of CMTM8 in bladder cancer results in reduced malignant cell growth, migration and invasion, which could make it a potential therapeutic target in the treatment of bladder cancer. |
| URI | http://hdl.handle.net/20.500.11897/417255 |
| ISSN | 1021-335X |
| DOI | 10.3892/or.2015.4310 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 人民医院 分子心血管学教育部重点实验室 |
