| Title | Genome-wide association study identifies two new susceptibility loci for colorectal cancer at 5q23.3 and 17q12 in Han Chinese |
| Authors | Jiang, Kewei Sun, Yimin Wang, Cheng Ji, Jiafu Li, Yaoping Ye, Yingjiang Lv, Liang Guo, Yong Guo, Sutang Li, Hai Zhang, Lianhai Zhou, Yanbing Jiang, Bo Ren, Yonghong Xu, Youchun Yang, Xiongfei Liu, Hongxia Wang, Yirui Shen, Zhanlong Qin, Wenyan Guo, Peng Jiang, Yuyang Hu, Zhibin Shen, Hongbing Cheng, Jing Yang, Yinxue Wang, Shan |
| Affiliation | Peking Univ, Peoples Hosp, Lab Surg Oncol, Dept Gen Surg, Beijing 100044, Peoples R China. Capital Bio Corp, Hlth Sci Res Inst, Beijing 102206, Peoples R China. Natl Engn Res Ctr Beijing Biochip Technol, Beijing 102206, Peoples R China. Tsinghua Univ, Grad Sch Shenzhen, State Key Lab Breeding Base, Shenzhen Key Lab Chem Biol, Shenzhen 518055, Peoples R China. Nanjing Med Univ, Clin Epidemiol Sect, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Ctr Canc, Nanjing 211166, Jiangsu, Peoples R China. Nanjing Med Univ, Dept Epidemiol & Biostat, Nanjing 211166, Jiangsu, Peoples R China. Nanjing Med Univ, Minist Educ MOE, Key Lab Modern Toxicol, Sch Publ Hlth, Nanjing 211166, Jiangsu, Peoples R China. Nanjing Med Univ, State Key Lab Reprod Med, Nanjing 210029, Jiangsu, Peoples R China. Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Dept Surg,Minist Educ, Beijing 100142, Peoples R China. Shanxi Med Univ, Affiliated Canc Hosp, Shanxi Canc Hosp & Inst, Dept Colorectal Surg, Taiyuan 030001, Peoples R China. Natl Engn Res Ctr Beijing Biochip Technol, Shanxi Branch Ctr, Taiyuan, Peoples R China. Qingdao Univ, Coll Med, Affiliated Hosp, Dept Gen Surg, Qingdao 266003, Peoples R China. Tsinghua Univ, Sch Med, Med Syst Biol Res Ctr, Dept Biomed Engn, Beijing 100084, Peoples R China. Shanxi Med Univ, Affiliated Canc Hosp, Shanxi Canc Hosp & Inst, Dept Mol Biol, Taiyuan 030001, Peoples R China. Ningxia Med Univ, Gen Hosp, Dept Anal Colorectal Surg, Yinchuan 750004, Peoples R China. Gansu Prov Peoples Hosp, Anorectal Dept, Lanzhou 730000, Peoples R China. Tsinghua Univ, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100084, Peoples R China. Natl Engn Res Ctr Beijing Biochip Technol, Ningxia Branch Ctr, Yinchuan 750004, Peoples R China. |
| Keywords | GWAS colorectal cancer association SENSING ION CHANNELS RISK POPULATION METAANALYSIS INFLAMMATION HINT1 SCAN SUPPRESSOR EXPRESSION VARIANT |
| Issue Date | 2015 |
| Publisher | ONCOTARGET |
| Citation | ONCOTARGET.2015,6,(37),40327-40336. |
| Abstract | Genome-wide association studies (GWAS) have reported a number of loci harboring common variants that influence risk of colorectal cancer (CRC) in European descent. But all the SNPs identified explained a small fraction of total heritability. To identify more genetic factors that modify the risk of CRC, especially Chinese Han specific, we conducted a three-stage GWAS including a screening stage (932 CRC cases and 966 controls) and two independent validations (Stage 2: 1,759 CRC cases and 1,875 controls; Stage 3: 943 CRC cases and 1,838 controls). In the combined analyses, we discovered two novel loci associated with CRC: rs12522693 at 5q23.3 (CDC42SE2-CHSY3, OR = 1.31, P = 2.08 x 10(-8)) and rs17836917 at 17q12 (ASIC2-CCL2, OR = 0.75, P = 4.55 x 10(-8)). Additionally, we confirmed two previously reported risk loci, rs6983267 at 8q24.21 (OR = 1.17, P = 7.17 x 10(-7)) and rs10795668 at 10p14 (OR = 0.86, P = 2.96 x 10(-6)) in our cohorts. These results bring further insights into the CRC susceptibility and advance our understanding on etiology of CRC. |
| URI | http://hdl.handle.net/20.500.11897/417167 |
| ISSN | 1949-2553 |
| DOI | 10.18632/oncotarget.5530 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 人民医院 北京肿瘤医院 |
