| Title | Polymer-Doxorubicin Conjugate Micelles Based on Poly(ethylene glycol) and Poly(N-(2-hydroxypropyl) methacrylamide): Effect of Negative Charge and Molecular Weight on Biodistribution and Blood Clearance |
| Authors | Yu, Qingsong Wei, Zhenke Shi, Jiyun Guan, Shuli Du, Nan Shen, Tong Tang, Hao Jia, Bing Wang, Fan Gan, Zhihua |
| Affiliation | Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing Lab Biomed Mat, Coll Life Sci & Technol, Beijing 100029, Peoples R China. Chinese Acad Sci, Inst Chem, CAS Key Lab Engn Plast, Beijing 100190, Peoples R China. Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China. |
| Keywords | IN-VIVO GLOMERULAR-FILTRATION HPMA COPOLYMERS N-(2-HYDROXYPROPYL)METHACRYLAMIDE COPOLYMERS TUMOR ACCUMULATION BLOCK-COPOLYMERS DRUG-DELIVERY TOMOGRAPHY CANCER THERAPEUTICS |
| Issue Date | 2015 |
| Publisher | BIOMACROMOLECULES |
| Citation | BIOMACROMOLECULES.2015,16,(9),2645-2655. |
| Abstract | Well-defined water-soluble block copolymers poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide-co-N-methacryloylglycylglycine) (PEG-b-P (HPMA-co-MAGG)) and their doxorubicin (Dox) conjugates with different composition and molecular weight were synthesized. These Dox conjugates can form micelles in buffer solution. The physicochemical properties, in vivo biodistribution, blood clearance, and especially the tumor accumulation of copolymers and micelles were studied. Severe liver accumulation can be observed for PEG-b-PMAGG copolymers. This was quite different from their Dox conjugate for which decreased RES uptake and elevated kidney accumulation could be observed. When decrease the negative charge to an appropriate amount such as 8-10 mol %, both RES uptake and kidney accumulation could be suppressed. Obvious tumor accumulation could be achieved especially when the molecular weight were increased from similar to 40 to similar to 80 KDa. These results provided us with a guideline for the design of nanoscaled drug delivery system as well as a potential option for treating kidney-related cancers. |
| URI | http://hdl.handle.net/20.500.11897/416668 |
| ISSN | 1525-7797 |
| DOI | 10.1021/acs.biomac.5b00460 |
| Indexed | SCI(E) EI PubMed |
| Appears in Collections: | 医学部待认领 |
