| Title | High Frequency Repetitive Transcranial Magnetic Stimulation Therapy For Chronic Neuropathic Pain: A Meta-analysis |
| Authors | Jin, Yu Xing, Guoqiang Li, Guangming Wang, Anguo Feng, Shenggang Tang, Qing Liao, Xiang Guo, Zhiwei McClure, Morgan A. Mu, Qiwen |
| Affiliation | Luzhou Med Coll, Luzhou, Peoples R China. Nanchong Cent Hosp, Imaging Inst Rehabil & Dev Brain Funct, North Sichuan Med Coll, Clin Med Coll 2, Nanchong, Peoples R China. John Hopkins Univ MCC, Lotus Biotech Com LLC, Rockville, MD USA. Peking Univ, Hosp 3, Beijing 100191, Peoples R China. North Sichuan Med Univ, Imaging Inst Rehabil & Dev Brain Funct, Nanchong Cent Hosp, 97 South Renmin Rd, Nanchong 637000, Sichuan, Peoples R China. |
| Keywords | High frequency repetitive transcranial magnetic stimulation neuropathic pain single stimulation multiple stimulation meta-analysis SPINAL-CORD-INJURY PRIMARY MOTOR CORTEX INTRACTABLE DEAFFERENTATION PAIN CENTRAL POSTSTROKE PAIN GENERAL-POPULATION DOUBLE-BLIND RTMS RELIEF RECOMMENDATIONS PERCEPTION |
| Issue Date | 2015 |
| Publisher | PAIN PHYSICIAN |
| Citation | PAIN PHYSICIAN.2015,18,(6),E1029-E1046. |
| Abstract | Background: Increasing evidence supports an analgesic effect of repetitive transcranial magnetic stimulation (rTMS) for neuropathic pain (NP). However, the optimal parameters of rTMS (stimulation frequency and treatment sessions) for achieving long-term analgesic effects remain unknown. This study analyzed the current findings in the literature. Objective: The aim of this study was to assess the optimal parameters of rTMS for NP, including the rTMS sessions needed for inducing acute as well as long-term analgesic effects. Study Design: A meta-analysis of the analgesic effect of high frequency rTMS (HF-rTMS) for neuropathic patients. Setting: This meta-analysis examined all studies involving the analgesic efficacy of HF-rTMS for NP. Methods: PubMed, Embase, and the Cochrane library were searched for clinical studies of rTMS treatment on NP published before December 31, 2014. Crude standardized mean differences (SMD) with 95% confidence interval (CI) were calculated for pain intensity after different treatment sessions (from 1 to 10) and follow-up of one or 2 months after rTMS treatment using random effect models. Results: Twenty-five studies (including 32 trials and 589 patients) were selected for the meta-analysis according to the inclusion and exclusion criteria. All 3 HF-rTMS treatments (5, 10, and 20 Hz) produced pain reduction, while there were no differences between them, with the maximal pain reduction found after one and 5 sessions of rTMS treatment. Further, this significant analgesic effect remained forone month after 5 sessions of rTMS treatment. Limitations: There are limitations of this meta-analysis. For example, the long-term analgesic effects of different HF-rTMS and low frequency (LF) rTMS sessions, including the single session of rTMS on different NP of varying origins have yet not been evaluated; the full degree of pain relief is still unclear for many rTMS studies. Conclusions: HF-rTMS stimulation on primary motor cortex is effective in relieving pain in NP patients. Although 5 sessions of rTMS treatment produced a maximal analgesic effect and may be maintained for at least one month, further large-scale and well-controlled trials are needed to determine if this enhanced effect is specific to certain types of NP such as post-stroke related central NP. |
| URI | http://hdl.handle.net/20.500.11897/416513 |
| ISSN | 1533-3159 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第三医院 |
