| Title | Hepatitis E vaccine immunization for rabbits to prevent animal HEV infection and zoonotic transmission |
| Authors | Zhang, Yulin Zeng, Hang Liu, Peng Liu, Lin Xia, Junke Wang, Lin Zou, Qinghua Wang, Ling Zhuang, Hui |
| Affiliation | Peking Univ Hlth Sci Ctr, Sch Basic Med Sci, Dept Microbiol & Infect Dis Ctr, Beijing 100191, Peoples R China. Peking Univ Hlth Sci Ctr, Sch Basic Med Sci, Dept Microbiol & Infect Dis Ctr, 38 Xueyuan Rd, Beijing 100191, Peoples R China. |
| Keywords | Hepatitis E virus Zoonotic transmission Rabbits HEV 239 vaccine Immunization strategy E VIRUS-INFECTION ORGAN-TRANSPLANT RECIPIENTS CHRONIC LIVER-DISEASE WILD BOAR MEAT DEVELOPED-COUNTRIES UNITED-STATES BLOOD-DONORS FOOD-BORNE GENOTYPE CHINA |
| Issue Date | 2015 |
| Publisher | VACCINE |
| Citation | VACCINE.2015,33,(38),4922-4928. |
| Abstract | Hepatitis E virus (HEV) infection has become a significant global public health concern as increasing cases of acute and chronic hepatitis E are reported. HEV of animal origin was proved to be a possible source of human infection and a previous study showed that the recent licensed HEV 239 vaccine can serve as a candidate vaccine to manage animal sources of HEV infection. However, previous immunization strategy for rabbits was the same as that for human, which is too costly to conduct large-scale animal vaccination. In an effort to reduce the costs, three vaccination schemes were assessed in the present study. Forty specific pathogen-free (SPF) rabbits were divided randomly into five groups with eight animals for each and inoculated intramuscularly with different doses of HEV 239 and placebo, respectively. All animals were challenged intravenously with swine HEV-4 and rabbit HEV of different titers 7 weeks after the initial immunization and then fecal virus excretion was monitored for 10 weeks. The results indicated that immunizing rabbits with two 10 mu g doses of the vaccine is superior to vaccination with two 20 mu g doses or a single 30 mu g dose, which can protect rabbits against homologous and heterologous HEV infection. These findings could enable implementation of large-scale animal vaccination to prevent rabbit HEV infection and zoonotic transmission. (C) 2015 Elsevier Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/416308 |
| ISSN | 0264-410X |
| DOI | 10.1016/j.vaccine.2015.07.040 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 基础医学院 |
