| Title | Late-onset Epstein-Barr virus-related disease in acute leukemia patients after haploidentical hematopoietic stem cell transplantation is associated with impaired early recovery of T and B lymphocytes |
| Authors | Liu, Jiangying Yan, Chenhua Zhang, Chunli Xu, Lanping Liu, Yanrong Huang, Xiaojun |
| Affiliation | Peking Univ, Peking Univ Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100871, Peoples R China. 11 Xizhimen South St, Beijing 100044, Peoples R China. |
| Keywords | acute leukemia EBV-related disease Epstein-Barr virus hematopoietic stem cell transplantation immune reconstitution BONE-MARROW-TRANSPLANTATION ACUTE MYELOID-LEUKEMIA IMMUNE RECONSTITUTION LYMPHOPROLIFERATIVE DISEASE HEMATOLOGICAL MALIGNANCIES COUNTS LONG SCT |
| Issue Date | 2015 |
| Publisher | CLINICAL TRANSPLANTATION |
| Citation | CLINICAL TRANSPLANTATION.2015,29,(10),904-910. |
| Abstract | Epstein-Barr virus-related disease (EBVD) is a serious clinical complication in patients who have undergone haploidentical hematopoietic stem cell transplantation (haploHSCT). Some recipients develop EBVD relatively late after haploHSCT, and most of these patients suffer a poor outcome. This retrospective cohort study characterized the early adaptive immune recovery of patients with acute leukemia presenting with EBVD more than 100d after haploHSCT. Patients with acute leukemia who received haploHSCT and developed EBVD 100d later (n=8) were compared with a matched control group without EBVD (n=24) with regard to peripheral WBC, lymphocytes, and neutrophils (at 30, 60, and 90d) and recoveries of B and T lymphocytes (at 30 and 90d, via immunophenotyping/flow cytometry). Ninety days after haploHSCT, the median values of WBCs and lymphocytes, and the recoveries of CD19(+) B cells and CD4(+), CD8(+), and CD4(+)CD45RO(+) T cells, were significantly lower in patients who developed EBVD, relative to the control group. These results suggest a significant association between deficient early recovery of B and T lymphocytes and the development of late-onset EBVD after haploHSCT. Our observation could facilitate clinical intervention and the improvement of overall survival of patients undergoing haploHSCT. |
| URI | http://hdl.handle.net/20.500.11897/415925 |
| ISSN | 0902-0063 |
| DOI | 10.1111/ctr.12593 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 人民医院 |
