| Title | Anticancer activity on prostate cancer of the extracts of prescription of TCM 921 |
| Authors | Li, Jiangbin Li, Hongyan Zhang, Zhihong Chen, Xiaoguang Ye, Zuguang Guo, Yinglu |
| Issue Date | 2008 |
| Publisher | 开云app体育 学报 自然科学版 |
| Citation | Beijing Daxue Xuebao (Ziran Kexue Ban)/Acta Scientiarum Naturalium Universitatis Pekinensis.2008,44,(4),511-516. |
| Abstract | In order to investigate the inhibition of the extracts of prescription of 921 on prostate cancer cell proliferation in vitro and tumor growth in vivo, the authors used the methods as follows: SRB assay was applied to examine the anti-proliferation of the extracts of prescription of 921 in vitro both on human cancer cell DU-145, PC-3m, EJ and mice prostate cancer TRAMP-C2. The experimental implanted tumor mice model Hepatoma (H22), Sarcoma (S180), Prostate cancer (TRAMP-C2) and tumor nude mice model Prostate cancer (PC-3M) were used to evaluate its anti-tumor activity in vivo. Furthermore, the enhance therapeutic effect was also observed when combined with cyclophosphamide (CTX) on S180. The results were 1) the extracts of prescription of 921 showed proliferation inhibitory activities on DU-145, PC-3M, EJ and TRAMP-C2 cell lines; 2) it inhibited mice H22, S180, TRAMP-C2 and naked mice PC-3M when administered i.g. at 3.6~14.3 g/(kg ?? day) for 9 days. The extracts of prescription of 921 enhanced CTX's therapeutic effect and didn't enhance its toxicity. In summary, the extracts of prescription of 921 showed inhibitory activity on the growth of prostate cancer. |
| URI | http://hdl.handle.net/20.500.11897/408909 |
| ISSN | 0479-8023 |
| Indexed | EI |
| Appears in Collections: | 待认领 |
