| Title | Association of interleukin-12 p40 gene 3 '-untranslated region polymorphism and outcome of HCV infection |
| Authors | Yin, Li-Min Zhu, Wan-Fu Wei, Lai Xu, Xiao-Yuan Sun, De-Gui Wang, Yan-Bin Fan, Wen-Mei Yu, Min Tian, Xiu-Lan Wang, Qi-Xin Gao, Yan Zhuang, Hui |
| Affiliation | Peking Univ, Dept Microbiol, Sch Basic Med Sci, Beijing 100083, Peoples R China. Peking Univ, Dept Infect Dis, Hosp 1, Beijing 100034, Peoples R China. Peking Univ, Inst Hepatol, Peoples Hosp, Beijing 100044, Peoples R China. Guan Stn Dis Prevent & Control, Guan 102700, Hebei Province, Peoples R China. Beijing Ditan Hosp, Beijing 100730, Peoples R China. |
| Keywords | HEPATITIS-C VIRUS RECOMBINANT HUMAN INTERLEUKIN-12 IMMUNE-RESPONSES INNATE RESISTANCE ADAPTIVE IMMUNITY NATURAL-HISTORY IL-12 SUSCEPTIBILITY PERSISTENCE THERAPY |
| Issue Date | 2004 |
| Publisher | world journal of gastroenterology |
| Citation | WORLD JOURNAL OF GASTROENTEROLOGY.2004,10,(16),2330-2333. |
| Abstract | AIM: To investigate the effect of interleukin-12 p40 gene (IL12B) 3'-untranslated region polymorphism on the outcome of HCV infection. METHODS: A total of 133 patients who had been infected with HCV for 12-25 (18.2 +/- 3.8) years, were enrolled in this study. Liver biochemical tests were performed with an automated analyzer and HCV RNA was detected by fluorogenic quantitative polymerase chain reaction. B-mode ultrasound was used for liver examination. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for the detection of IL12B (1188A/C) polymorphism. RESULTS: Self-limited infection was associated with AC genotype (OR = 3.48; P = 0.001) and persistent infection was associated with AA genotype (OR = 0.34; P = 0.014) at site 1188 of IL12B. In patients with persistent HCV infection, no significant differences were found regarding the age, gender, duration of infection and biochemical characteristics (P>0.05). According to B-mode ultrasound imaging and clinical diagnosis, patients with persistent infection were divided into groups based on the severity of infection. No significant differences were found in the frequency of IL-12 genotype (1188A/C) between different groups (P>0.05). CONCLUSION: The polymorphism of IL12B (1188A/C) appears to have some influence on the outcome of HCV infection. |
| URI | http://hdl.handle.net/20.500.11897/400077 |
| ISSN | 1007-9327 |
| Indexed | SCI(E) |
| Appears in Collections: | 基础医学院 第一医院 人民医院 |
