| Title | New Isocoumarins from a Cold-Adapted Fungal Strain Mucor sp and Their Developmental Toxicity to Zebrafish Embryos |
| Authors | Feng, Chun-Chi Chen, Guo-Dong Zhao, Yan-Qiu Xin, Sheng-Chang Li, Song Tang, Jin-Shan Li, Xiao-Xia Hu, Dan Liu, Xing-Zhong Gao, Hao |
| Affiliation | Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China. Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China. Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, Key Lab Chem Genom, Shenzhen 518055, Peoples R China. South China Agr Univ, Dept Pharmaceut Engn, Guangzhou 510642, Guangdong, Peoples R China. |
| Keywords | ASPERGILLUS-AWAMORI ACID-DERIVATIVES CYCLIC-PEPTIDES PENICILLIUM POLYKETIDES METABOLITES |
| Issue Date | 2014 |
| Publisher | chemistry biodiversity |
| Citation | CHEMISTRY & BIODIVERSITY.2014,11,(7),1099-1108. |
| Abstract | Three new isocoumarin derivatives, mucorisocoumarins A-C (1-3, resp.), together with seven known compounds, 4-10, were isolated from the cold-adapted fungal strain Mucor sp. (No. XJ07027-5). The structures of the new compounds were identified by detailed IR, MS, and 1D-and 2D-NMR analyses. It was noteworthy that compounds 1, 2, 4, and 5 were successfully resolved by chiral HPLC, indicating that 1-7 should exist as enantiomers. In an embryonic developmental toxicity assay using a zebrafish model, compound 3 produced developmental abnormalities in the zebrafish embryos. This is the first report of isocoumarins with developmental toxicity to zebrafish embryos. |
| URI | http://hdl.handle.net/20.500.11897/396971 |
| ISSN | 1612-1872 |
| Indexed | SCI(E) |
| Appears in Collections: | 化学生物学与生物技术学院 |
