| Title | Adjuvant percutaneous radiofrequency ablation of feeding artery of hepatocellular carcinoma before treatment |
| Authors | Hou, Yi-Bin Chen, Min-Hua Yan, Kun Wu, Jin-Yu Yang, Wei |
| Affiliation | Peking Univ, Canc Hosp & Inst, Sch Oncol, Dept Ultrasound, Beijing 100142, Peoples R China. Peking Univ, Canc Hosp & Inst, Sch Oncol, Dept Ultrasound, 52 Fucheng Rd, Beijing 100142, Peoples R China. |
| Keywords | Hepatocellular carcinoma Feeding artery Radiofrequency ablation Recurrence Color Doppler flow imaging HEPATIC BLOOD-FLOW THERMAL ABLATION TISSUE ABLATION LIVER OCCLUSION THERAPY TUMORS CHEMOEMBOLIZATION MALIGNANCIES ELECTRODE |
| Issue Date | 2009 |
| Publisher | world journal of gastroenterology |
| Citation | WORLD JOURNAL OF GASTROENTEROLOGY.2009,15,(21),2638-2643. |
| Abstract | AIM: To evaluate the feasibility and efficacy of percutaneous radiofrequency ablation (RFA) of the feeding artery of hepatocellular carcinoma (HCC) in reducing the blood-flow-induced heat-sink effect of RFA. METHODS: A total of 154 HCC patients with 177 pathologically confirmed hypervascular lesions participated in the study and were randomly assigned into two groups. Seventy-one patients with 75 HCCs (average tumor size, 4.3 +/- 1.1 cm) were included in group A, in which the feeding artery of HCC was identified by color Doppler flow imaging, and were ablated with multiple small overlapping RFA foci [percutaneous ablation of feeding artery (PAA)] before routine RFA treatment of the tumor. Eighty-three patients with 102 HCC (average tumor size, 4.1 +/- 1.0 cm) were included in group B, in which the tumors were treated routinely with RFA. Contrast-enhanced computed tomography was used as post-RFA imaging, when patients were followed-up for 1, 3 and 6 mo. RESULTS: In group A, feeding arteries were blocked in 66 (88%) HCC lesions, and the size of arteries decreased in nine (12%). The average number of punctures per HCC was 2.76 +/- 1.12 in group A, and 3.36 +/- 1.60 in group B (P = 0.01). The tumor necrosis rate at 1 mo post-RFA was 90.67% (68/75 lesions) in group A and 90.20% (92/102 lesions) in group B. HCC recurrence rate at 6 mo post-RFA was 17.33% (13/75) in group A and 31.37% (32/102) in group B (P = 0.04). CONCLUSION: PAA blocked effectively the feeding artery of HCC. Combination of PAA and RFA significantly decreased post-RFA recurrence and provided an alternative treatment for hypervascular HCC. (C) 2009 The WJG Press and Baishideng. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/396961 |
| ISSN | 1007-9327 |
| DOI | 10.3748/wjg.15.2638 |
| Indexed | SCI(E) 中国科技核心期刊(ISTIC) 中国科学引文数据库(CSCD) |
| Appears in Collections: | 北京肿瘤医院 |
