| Title | Risk Factors for Human Illness with Avian Influenza A (H5N1) Virus Infection in China |
| Authors | Zhou, Lei Liao, Qiaohong Dong, Libo Huai, Yang Bai, Tian Xiang, Nijuan Shu, Yuelong Liu, Wei Wang, Shiwen Qin, Pengzhe Wang, Min Xing, Xuesen Lv, Jun Chen, Ray Y. Feng, Zijian Yang, Weizhong Uyeki, Timothy M. Yu, Hongjie |
| Affiliation | Peking Univ, Sch Publ Hlth, Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent,Off Dis Con, Beijing 100871, Peoples R China. Peking Univ, Sch Publ Hlth, Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent,State Key L, Beijing 100871, Peoples R China. Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China. Wuhan Ctr Dis Control & Prevent, Wuhan, Peoples R China. Hubei Prov Ctr Dis Control & Prevent, Wuhan, Peoples R China. Guangzhou Ctr Dis Control & Prevent, Guangzhou, Guangdong, Peoples R China. NIAID, NIH, Bethesda, MD 20892 USA. Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. China CDC, Off Dis Control & Emergency Response, 27 Nanwei Rd, Beijing 100050, Peoples R China. |
| Keywords | TO-PERSON TRANSMISSION HONG-KONG POULTRY DUCKS ASIA MARKETS VACCINATION EVOLUTION CHICKENS BIRDS |
| Issue Date | 2009 |
| Publisher | journal of infectious diseases |
| Citation | JOURNAL OF INFECTIOUS DISEASES.2009,199,(12),1726-1734. |
| Abstract | Background. In China, 30 human cases of avian influenza A (H5N1) virus infection were identified through July 2008. We conducted a retrospective case-control study to identify risk factors for influenza H5N1 disease in China. Methods. A questionnaire about potential influenza H5N1 exposures was administered to 28 patients with influenza H5N1 and to 134 randomly selected control subjects matched by age, sex, and location or to proxies. Conditional logistic regression analyses were performed. Results. Before their illness, patients living in urban areas had visited wet poultry markets, and patients living in rural areas had exposure to sick or dead backyard poultry. In multivariable analyses, independent risk factors for influenza H5N1 were direct contact with sick or dead poultry (odds ratio [OR], 506.6 [95% confidence interval {CI}, 15.7-16319.6]; P < .001), indirect exposure to sick or dead poultry (OR, 56.9 [95% CI, 4.3-745.6]; P = .002), and visiting a wet poultry market (OR, 15.4 [95% CI, 3.0-80.2]; P = .001). Conclusions. To prevent human influenza H5N1 in China, the level of education about avoiding direct or close exposures to sick or dead poultry should be increased, and interventions to prevent the spread of influenza H5N1 at live poultry markets should be implemented. |
| URI | http://hdl.handle.net/20.500.11897/396956 |
| ISSN | 0022-1899 |
| DOI | 10.1086/599206 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
