| Title | Changes in functional connectivity of ventral anterior cingulate cortex in heroin abusers |
| Authors | Wang Wei Wang Ya-rong Qin Wei Yuan Kai Tian Jie Li Qiang Yang Lan-ying Lu Lin Guo You-min |
| Affiliation | Xi An Jiao Tong Univ, Affiliated Hosp 1, Mol Imaging Ctr, Sch Med, Xian 710061, Shannxi, Peoples R China. Fourth Mil Med Univ, Dept Radiol, Tangdu Hosp, Xian 710038, Shaanxi, Peoples R China. Xidian Univ, Life Sci Res Ctr, Sch Elect Engn, Xian 710071, Shannxi, Peoples R China. Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China. Fourth Mil Med Univ, Dept Radiol, Tangdu Hosp, Xian 710038, Shannxi, Peoples R China. |
| Keywords | heroin ventral anterior cingulate cortex (vACC) functional MRI EPISODIC MEMORY RETRIEVAL DEFAULT MODE NETWORK HUMAN BRAIN PREFRONTAL CORTEX WORKING-MEMORY DRUG-ADDICTION NEURAL BASIS COCAINE DYSFUNCTION TASK |
| Issue Date | 2010 |
| Publisher | Chinese Medical Journal |
| Citation | CHINESE MEDICAL JOURNAL.2010,123,(12),1582-1588. |
| Abstract | Background Previous studies with animal experiments, autopsy, structural magnetic resonance imaging (MRI) and task-related functional MRI (fMRI) have confirmed that brain functional connectivity in addicts has become impaired. The goal of this study was to investigate the alteration of resting-state functional connectivity of the ventral anterior cingulate cortex (vACC) in the heroin abusers' brain. Methods Fifteen heroin abusers and fifteen matched healthy volunteers were studied using vACC as the region-of interest (ROI) seed. A 3.0 T scanner with a standard head coil was the imagining apparatus. T2*-weighted gradient-echo planar imaging (GRE-EPI) was the scanning protocol. A ROI seed based correlation analysis used a SPM5 software package as the tool for all images processing. Results This study showed a functional connection to the insula vACC in heroin abusers. Compared with controls, heroin users showed decreased functional connectivity between the nucleus accumbens (NAc) and vACC, between the parahippocampala gyrus/amgdala (PHC/amygdala) and vACC, between the thalamus and vACC, and between the posterior cingulated cortex/precuneus (PCC/pC) and vACC. Conclusion The altered resting-state functional connectivity to the vACC suggests the neural circuitry on which the addictive drug has an affect and reflects the dysfunction of the addictive brain. Chin Med J 2010;123(12):1582-1588 |
| URI | http://hdl.handle.net/20.500.11897/395726 |
| ISSN | 0366-6999 |
| DOI | 10.3760/cma.j.issn.0366-6999.2010.12.019 |
| Indexed | SCI(E) 中国科技核心期刊(ISTIC) |
| Appears in Collections: | 医学部待认领 |
