| Title | Direct Evidence for Hydroxyl Radical Scavenging Activity of Cerium Oxide Nanoparticles |
| Authors | Xue, Ying Luan, Qingfen Yang, Dan Yao, Xin Zhou, Kebin |
| Affiliation | Chinese Acad Sci, Grad Univ, Coll Chem & Chem Engn, Beijing 100049, Peoples R China. Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China. |
| Keywords | PROTECTION NANOCERIA ANTIOXIDANTS DISEASES INJURY DAMAGE |
| Issue Date | 2011 |
| Publisher | journal of physical chemistry c |
| Citation | JOURNAL OF PHYSICAL CHEMISTRY C.2011,115,(11),4433-4438. |
| Abstract | Cerium oxide (CeO2) nanoparticles have been considered as excellent antioxidants and have become a focus of numerous studies. However, the mechanism behind the antioxidant role in the complex biological system has not been well-understood. In this work, direct evidence for the hydroxyl radical ((OH)-O-center dot) scavenging activity of CeO2 nanoparticles was established by a simple photometric system in vitro. When methyl violet (MV) reacted with hydroxyl radical, the absorbance change indicated the hydroxyl radical level. The presence of CeO2 nanoparticles protected MV by competitively reacting with the (OH)-O-center dot, so their hydroxyl radical scavenging activity was directly seen through the absorbance change. This activity was also proved to be size-dependent and was believed to have a close correlation with Ce3+ at the surface of the particles. |
| URI | http://hdl.handle.net/20.500.11897/394977 |
| ISSN | 1932-7447 |
| DOI | 10.1021/jp109819u |
| Indexed | SCI(E) EI |
| Appears in Collections: | 天然药物与仿生药物国家重点实验室 |
