| Title | A Population-Based Clinical Trial Comparing Endocervical High-Risk HPV Testing Using Hybrid Capture 2 and Cervista From the SHENCCAST II Study |
| Authors | Belinson, Jerome L. Wu, Ruifang Belinson, Suzanne E. Qu, Xinfeng Yang, Bin Du, Hui Wu, Ruosong Wang, Chun Zhang, Lijie Zhou, Yanqiu Liu, Ying Pretorius, Robert G. |
| Affiliation | Prevent Oncol Int, Cleveland Hts, OH USA. Peking Univ, Shenzhen Hosp, Shenzhen, Peoples R China. Royal Ladies Clin, Shenzhen, Peoples R China. Cleveland Clin, Dept Anat Pathol, Cleveland, OH 44106 USA. Cleveland Clin, Dept Obstet & Gynecol, Cleveland, OH 44106 USA. Kaiser Permanente, Dept Obstet & Gynecol, Fontana, CA USA. 2762 Fairmt Blvd, Cleveland Hts, OH 44118 USA. |
| Keywords | Hybrid Capture 2 Cervista Cervical cancer screening Human papillomavirus HPV GRADE CERVICAL LESIONS HUMAN-PAPILLOMAVIRUS CANCER WOMEN PERFORMANCE CYTOLOGY DETECT HR |
| Issue Date | 2011 |
| Publisher | american journal of clinical pathology |
| Citation | AMERICAN JOURNAL OF CLINICAL PATHOLOGY.2011,135,(5),790-795. |
| Abstract | Our objective was to directly compare the accuracy of the high-risk human papillomavirus (HPV) assays, Hybrid Capture 2 (hc2; Qiagen, Gaithersburg, MD) and Cervista (Hologic, Bedford, MA), in diagnosing cervical intraepithelial neoplasia (CIN) 3 or worse (cancer). A population-based, cross-sectional study (The Shenzhen Cervical Cancer Screening Trial II) was conducted in Guangdong Province in China. Three high-risk HP V assays, self and direct cervical sampling and cytology, were studied. Abnormal results on any of 6 study tests (33%) resulted in referral to colposcopy. At colposcopy, every patient had at least 5 cervical biopsy specimens obtained. For 8,556 women between the ages of 25 and 59 years (mean, 38.9 years), the rate for CIN 3 or worse was 1.6% (141/8,556). The sensitivity (confidence interval) values for CIN 3 or worse were 97.9% (94.0%-99.6%) and 95.1% (90.0%-98.0%) for hc2 and Cervista, respectively (P > .05). The specificity (confidence interval) values were 87.8% (87.1%-88.5%) and 90.3% (89.6%-90.9%), respectively P < .05). Differences in accuracy in diagnosing CIN 3 or worse with the hc2 and Cervista tests are minor and result from the decisions made in selecting the cut points. |
| URI | http://hdl.handle.net/20.500.11897/394830 |
| ISSN | 0002-9173 |
| DOI | 10.1309/AJCPKA6ATAPBZ6JQ |
| Indexed | SCI(E) |
| Appears in Collections: | 深圳医院 |
