| Title | Characterization of HIV Type 1 env Gene in Cerebrospinal Fluid and Blood of Infected Chinese Patients |
| Authors | Wei, Feili Wang, Xicheng Liu, Lifeng Gao, Rong Shi, Ying Zhang, Yulin Qiao, Luxin Chen, Dexi |
| Affiliation | Capital Med Univ, Beijing You An Hosp, Dept Med, STD AIDS Res Ctr, Beijing 100069, Peoples R China. Yunnan Prov Hosp Infect Dis, Yunnan AIDS Care Ctr, Kunming, Yunnan Province, Peoples R China. Peking Univ, Biodynam Opt Imagine Ctr, Beijing 100871, Peoples R China. Beijing Liver Dis Inst, Beijing, Peoples R China. Capital Med Univ, Beijing You An Hosp, Dept Internal Med, Beijing 100069, Peoples R China. |
| Keywords | IMMUNODEFICIENCY-VIRUS TYPE-1 THERAPY CCR5 |
| Issue Date | 2011 |
| Publisher | 艾滋病研究和体逆转酶病毒 |
| Citation | AIDS RESEARCH AND HUMAN RETROVIRUSES.2011,27,(7),793-796. |
| Abstract | HIV infection in the central nervous system (CNS) can progress to AIDS dementia complex; currently, little information on the characterization of the HIV-1 env gene from the CNS is available in infected Chinese patients. In the study, the C2-V5 regions of the HIV envelope gene were cloned and sequenced from both cerebrospinal fluid (CSF) and blood samples of five infected Chinese patients. Sequence analysis revealed that the sequences from Yunan province clustered closely with subtypes CRF07_BC, CRF08_BC, and C, and the sequences from blood showed a significantly higher divergence from those from the CSF. In addition, as predicted by the 11/25 charge rule and geno2pheno program, most of the HIV viral quasispecies from both CSF and blood use CCR5 as coreceptor. These data provide valuable information on a detailed evaluation of the pathogenesis of HIV infection in different tissues of Chinese HIV-infected patients, and our findings would be helpful for the design of vaccines and therapy strategies. |
| URI | http://hdl.handle.net/20.500.11897/394701 |
| ISSN | 0889-2229 |
| DOI | 10.1089/aid.2010.0369 |
| Indexed | SCI(E) |
| Appears in Collections: | 待认领 |
