| Title | Genetic Effects and Modifiers of Radiotherapy and Chemotherapy on Survival in Pancreatic Cancer |
| Authors | Zeng, Hongmei Yu, Herbert Lu, Lingeng Jain, Dhanpat Kidd, Mark S. Saif, M. Wasif Chanock, Stephen J. Hartge, Patricia Risch, Harvey A. |
| Affiliation | Yale Univ, Dept Epidemiol & Publ Hlth, Sch Publ Hlth, New Haven, CT 06520 USA. Peking Univ, Key Lab Carcinogenesis & Translat Res, Beijing Canc Hosp & Inst, Minist Educ,Dept Canc Epidemiol,Sch Oncol, Beijing 100871, Peoples R China. Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06520 USA. Yale Univ, Sch Med, Dept Surg, New Haven, CT 06520 USA. Columbia Univ Coll Phys & Surg, Dept Med, Div Hematol Oncol, New York, NY 10032 USA. NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, Natl Inst Hlth,Dept Hlth & Human Serv, Bethesda, MD 20892 USA. Yale Univ, Dept Epidemiol & Publ Hlth, Sch Publ Hlth, POB 208034, New Haven, CT 06520 USA. |
| Keywords | pancreatic neoplasms survival genetic heterogeneity polymorphism single nucleotide prognosis SINGLE-NUCLEOTIDE POLYMORPHISMS ENDOTHELIAL GROWTH-FACTOR GENOME-WIDE ASSOCIATION S-TRANSFERASE-PI INCREASED EXPRESSION GEMCITABINE ADENOCARCINOMA TRIAL ALPHA-1-ANTITRYPSIN SUSCEPTIBILITY |
| Issue Date | 2011 |
| Publisher | pancreas |
| Citation | PANCREAS.2011,40,(5),657-663. |
| Abstract | Objectives: Germ-line genetic variation may affect clinical outcomes of cancer patients. We applied a candidate-gene approach to evaluate the effect of putative markers on survival of patients with pancreatic cancer. We also examined gene-radiotherapy and gene-chemotherapy interactions, aiming to explain interindividual differences in treatment outcomes. Methods: In total, 211 patients with pancreatic cancer were recruited in a population-based study. Sixty-four candidate genes associated with cancer survival or treatment response were selected from existing publications. Genotype information was obtained from a previous genome-wide association study data set. The main effects of genetic variation and gene-specific treatment interactions on overall survival were examined by proportional hazards regression models. Results: Fourteen genes showed evidence of association with pancreatic cancer survival. Among these, rs1760217, located at the DPYD gene; rs17091162 at SERPINA3; and rs2231164 at ABCG2 had the lowest P of 10(-4.60), 0.0013, and 0.0023, respectively. We also observed that 2 genes, RRM1 and IQGAP2, had significant interactions with radiotherapy in association with survival, and 2 others, TYMS and MET, showed evidence of interaction with 5-fluorouracil and erlotinib, respectively. Conclusions: Our study suggested significant associations between germ-line genetic polymorphisms and overall survival in pancreatic cancer, as well as survival interactions between various genes and radiotherapy and chemotherapy. |
| URI | http://hdl.handle.net/20.500.11897/394700 |
| ISSN | 0885-3177 |
| DOI | 10.1097/MPA.0b013e31821268d1 |
| Indexed | SCI(E) |
| Appears in Collections: | 北京肿瘤医院 |
