| Title | Circulating neuregulin-1 beta levels vary according to the angiographic severity of coronary artery disease and ischemia |
| Authors | Geisberg, Carrie Anna Wang, Guisong Safa, Radwan N. Smith, Holly M. Anderson, Brent Peng, Xu-Yang Veerkamp, Brian Zhao, David X. Blakemore, Dana Yu, Chang Sawyer, Douglas B. |
| Affiliation | Vanderbilt Univ, Sch Med, Div Cardiovasc Med, Nashville, TN 37232 USA. Vanderbilt Univ, Sch Med, Dept Biostat, Nashville, TN 37232 USA. Boston Univ, Sch Med, Boston, MA 02118 USA. Peking Univ, Hosp 3, Dept Cardiol, Beijing 100871, Peoples R China. Vanderbilt Univ, Sch Med, Div Cardiovasc Med, 2220 Pierce Ave,361 PRB, Nashville, TN 37232 USA. |
| Keywords | atherosclerosis biomarkers growth factors neuregulin stress-induced ischemia ENDOTHELIAL GROWTH-FACTOR HEART-FAILURE EXPRESSION HEREGULIN PLASMA VEGF ATHEROSCLEROSIS CELLS |
| Issue Date | 2011 |
| Publisher | coronary artery disease |
| Citation | CORONARY ARTERY DISEASE.2011,22,(8),577-582. |
| Abstract | Background Coronary artery disease (CAD) is the leading killer in the United States. Patients with severe CAD and ischemia have worse prognosis. Therefore expansion of biomarker research, to identify at-risk individuals and explain the complex biology between cardiovascular growth factors and atherosclerosis is needed. Neuregulin-1 beta (NRG-1 beta) is a myocardial stress activated growth and survival factor released from endocardial and endothelial cells. NRG-1 beta is essential for cardiovascular development and a regulator of angiogenesis. We postulated that plasma and serum levels of NRG-1 beta would vary in relation to CAD severity and the presence of stress-induced ischemia. Methods We measured serum and plasma levels of NRG-1 beta and vascular endothelial growth factor (VEGF) in 60 patients undergoing cardiac catheterization. CAD severity was calculated from angiographic results using a modified Duke jeopardy score. Results Serum NRG-1 beta (sNRG-1 beta), plasma NRG-1 beta (pNRG-1 beta), serum VEGF, and plasma VEGF were detectable in the majority of patients. The pNRG-1 beta levels were approximately two-fold higher than sNRG-1 beta. Both sNRG-1 beta and pNRG-1 beta correlated inversely with CAD severity. pNRG-1 beta levels were statistically higher in patients with stress-induced ischemia denoted by a positive myocardial perfusion imaging study that correlated with angiographic findings (P = 0.02). Conclusion Both sNRG-1 beta and pNRG-1 beta correlated inversely with angiographic severity of CAD. pNRG-1 beta levels were two-fold higher than serum and were higher in patients with stress-induced ischemia. Therefore we conclude that plasma is the optimal source for the further exploration of the biological significance of NRG-1 beta as a biomarker of CAD severity and ischemia. Coron Artery Dis 22: 577-582 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
| URI | http://hdl.handle.net/20.500.11897/394171 |
| ISSN | 0954-6928 |
| DOI | 10.1097/MCA.0b013e32834d3346 |
| Indexed | SCI(E) |
| Appears in Collections: | 第三医院 |
