| Title | Synthesis, Characterization, and Reactivity of N-Acyl Chloroformamidines: Useful Building Blocks for the Construction of N-Acyl-Substituted 1,1-Diaminoethylenes, Amidines, Ureas, and Thioureas |
| Authors | Wang, Yang Chi, Yue Zhao, Fei Zhang, Wen-Xiong Xi, Zhenfeng |
| Affiliation | Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, BNLMS,Coll Chem, Beijing 100871, Peoples R China. Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China. |
| Keywords | carbodiimide N-acyl chloroformamidine 1,1-diaminoethylene amidine urea EFFICIENT MULTICOMPONENT REACTIONS EARTH-METAL COMPLEXES COORDINATION CHEMISTRY CATALYTIC ADDITION C-N CARBODIIMIDE CHEMISTRY GUANIDINATE LIGANDS UBER CARBODIIMIDE TERMINAL ALKYNES SECONDARY-AMINES |
| Issue Date | 2013 |
| Publisher | synthesis stuttgart |
| Citation | SYNTHESIS-STUTTGART.2013,45,(3),347-354. |
| Abstract | The systematic synthesis of a series of N-acyl chloroformamidines is achieved by reaction of carbodiimides with acid chlorides; the structure of an N-acyl chloroformamidine was confirmed by X-ray diffraction. The reactivity of N-acyl chloroformamidines towards diethyl malonate, phenylethynyllithium, pentane-2,4-dione, methyl acetoacetate, water, 1,3-dimethylurea, 1,3-dimethylthiourea, and sodium hydrosulfide, resulted in unique protocols for the synthesis of N-acyl-substituted 1,1-diaminoethylenes, amidines, ureas, and thioureas, respectively. These results show that N-acyl chloroformamidines have a good ability to accept nucleophilic attack for the construction of useful N-containing compounds. |
| URI | http://hdl.handle.net/20.500.11897/394026 |
| ISSN | 0039-7881 |
| DOI | 10.1055/s-0032-1316833 |
| Indexed | SCI(E) |
| Appears in Collections: | å å¦ä¸ å å å·¥ç¨ å¦é ¢ 生物有机与分子工程教育部重点实验室 |
