Title | Reduced Striatal Dopamine Transporters in People with Internet Addiction Disorder |
Authors | Hou, Haifeng Jia, Shaowe Hu, Shu Fan, Rong Sun, Wen Sun, Taotao Zhang, Hong |
Affiliation | Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Nucl Med, Hangzhou 310009, Zhejiang, Peoples R China. Zhejiang Univ, Med PET Ctr, Hangzhou 310009, Zhejiang, Peoples R China. Zhejiang Univ, Inst Nucl Med & Mol Imaging, Hangzhou 310009, Zhejiang, Peoples R China. Key Lab Med Mol Imaging Zhejiang Prov, Hangzhou 310009, Zhejiang, Peoples R China. Peking Univ, Shenzhen Hosp, Dept Nucl Med, Shenzhen 310009, Peoples R China. |
Keywords | DEPENDENT PATIENTS HEROIN USERS VIDEO GAME RELEASE METHAMPHETAMINE TOMOGRAPHY ABSTINENCE MARKERS ABUSERS GENES |
Issue Date | 2012 |
Publisher | journal of biomedicine and biotechnology |
Citation | JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY.2012. |
Abstract | In recent years, internet addiction disorder (IAD) has become more prevalent worldwide and the recognition of its devastating impact on the users and society has rapidly increased. However, the neurobiological mechanism of IAD has not bee fully expressed. The present study was designed to determine if the striatal dopamine transporter (DAT) levels measured by Tc-99m-TRODAT-1 single photon emission computed tomography (SPECT) brain scans were altered in individuals with IAD. SPECT brain scans were acquired on 5 male IAD subjects and 9 healthy age-matched controls. The volume (V) and weight (W) of bilateral corpus striatum as well as the Tc-99m-TRODAT-1 uptake ratio of corpus striatum/the whole brain (Ra) were calculated using mathematical models. It was displayed that DAT expression level of striatum was significantly decreased and the V, W, and Ra were greatly reduced in the individuals with IAD compared to controls. Taken together, these results suggest that IAD may cause serious damages to the brain and the neuroimaging findings further illustrate IAD is associated with dysfunctions in the dopaminergic brain systems. Our findings also support the claim that IAD may share similar neurobiological abnormalities with other addictive disorders. |
URI | http://hdl.handle.net/20.500.11897/393926 |
ISSN | 1110-7243 |
DOI | 10.1155/2012/854524 |
Indexed | SCI(E) |
Appears in Collections: | 深圳医院 |