| Title | Common Use of Antipsychotic Polypharmacy in Older Asian Patients With Schizophrenia (2001-2009) |
| Authors | Xiang, Yu-Tao Dickerson, Faith Kreyenbuhl, Julie Ungvari, Gabor S. Wang, Chuan-Yue Si, Tian-Mei Lee, Edwin H. M. He, Yan-Ling Chiu, Helen F. K. Yang, Shu-Yu Chong, Mian-Yoon Tan, Chay-Hoon Kua, Ee-Heok Fujii, Senta Sim, Kang Yong, Michael K. H. Trivedi, Jitendra K. Chung, Eun-Kee Udomratn, Pichet Chee, Kok-Yoon Sartorius, Norman Shinfuku, Naotaka |
| Affiliation | Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China. Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China. Univ Maryland, Sch Med, Dept Psychiat, Div Res Serv, Baltimore, MD 21201 USA. Stanley Res Program Sheppard Pratt, Stanley, Hong Kong, Peoples R China. Mental Illness Res Educ & Clin Ctr, Vet Adm Capitol Healthcare Network VISN 5, Baltimore, MD USA. Univ Notre Dame, Marian Ctr, Perth, WA, Australia. Minist Mental Hlth, Key Lab Mental Hlth, Beijing, Peoples R China. Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China. Shanghai Mental Hlth Ctr, Shanghai, Peoples R China. Taipei City Hosp, Taipei, Taiwan. Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Kaohsiung, Taiwan. Chang Gung Univ, Sch Med, Kaohsiung, Taiwan. Natl Univ Singapore, Singapore 117548, Singapore. Hyogo Inst Traumat Stress, Kobe, Hyogo, Japan. CSM Med Univ UP, Dept Psychiat, Lucknow, Uttar Pradesh, India. Natl Seoul Hosp, Seoul, South Korea. Prince Songkla Univ, Hat Yai, Thailand. Kuala Lumpur Hosp, Tunku Abdul Rahman Inst Neurosci, Dept Psychiat & Mental Hlth, Kuala Lumpur, Malaysia. Assoc Improvement Mental Hlth Programs, Geneva, Switzerland. Seinan Gakuin Univ Fukuoka, Fukuoka, Japan. Chinese Univ Hong Kong, Tai Po Hosp, Multictr, Dept Psychiat, Ground Floor, Tai Po, Hong Kong, Peoples R China. |
| Keywords | schizophrenia prescription patterns antipsychotic polypharmacy psychogeriatric patients Asia EAST-ASIA SPECTRUM DISORDERS DRUG PRESCRIPTION RISPERIDONE EFFICACY TRENDS RISKS |
| Issue Date | 2012 |
| Publisher | 临床精神药理学杂志 |
| Citation | JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY.2012,32,(6),809-813. |
| Abstract | Objective: The aim of this study was to survey the use of antipsychotic polypharmacy (APP) in older Asian patients with schizophrenia and examine its demographic and clinical correlates. Methods: Information on hospitalized patients with schizophrenia aged 55 or older was extracted from the database of the Research on Asian Psychotropic Prescription Patterns study. Data on 1439 patients in 6 Asian countries and territories including China, Hong Kong, Japan, Korea, Singapore, and Taiwan were analyzed. Sociodemographic and clinical characteristics and antipsychotic prescriptions were recorded using a standardized protocol and data collection procedure. Results: The frequency of APP prescription was 51.6% in the pooled sample with wide intercountry variations. Multiple logistic regression analysis of the whole sample showed that patients on APP had higher antipsychotic doses and also were more likely to receive first-generation antipsychotics. Conclusions: Use of APP was common in older Asian patients with schizophrenia. Given the limited evidence supporting its efficacy, the potentially severe side effects and high costs, APP should be used with caution in this population. The reasons for and outcomes of the use of APP in this patient population merit further exploration. |
| URI | http://hdl.handle.net/20.500.11897/392505 |
| ISSN | 0271-0749 |
| DOI | 10.1097/JCP.0b013e3182726623 |
| Indexed | SCI(E) |
| Appears in Collections: | 第六医院 |
