| Title | Coupling of functional connectivity and regional cerebral blood flow reveals a physiological basis for network hubs of the human brain |
| Authors | Liang, Xia Zou, Qihong He, Yong Yang, Yihong |
| Affiliation | NIDA, Neuroimaging Res Branch, NIH, Baltimore, MD 21224 USA. Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China. Peking Univ, MRI Res Ctr, Beijing 100871, Peoples R China. Peking Univ, Beijing City Key Lab Med Phys & Engn, Beijing 100871, Peoples R China. |
| Keywords | fMRI connectomics graph theory modularity metabolism WORKING-MEMORY TASKS CORTICAL HUBS RESTING-STATE CORTEX ACTIVATION FMRI ORGANIZATION CONSUMPTION COGNITION DEFAULT |
| Issue Date | 2013 |
| Publisher | proceedings of the national academy of sciences of the united states of america |
| Citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.2013,110,(5),1929-1934. |
| Abstract | Human brain functional networks contain a few densely connected hubs that play a vital role in transferring information across regions during resting and task states. However, the relationship of these functional hubs to measures of brain physiology, such as regional cerebral blood flow (rCBF), remains incompletely understood. Here, we used functional MRI data of blood-oxygenation-level-dependent and arterial-spin-labeling perfusion contrasts to investigate the relationship between functional connectivity strength (FCS) and rCBF during resting and an N-back working-memory task. During resting state, functional brain hubs with higher FCS were identified, primarily in the default-mode, insula, and visual regions. The FCS showed a striking spatial correlation with rCBF, and the correlation was stronger in the default-mode network (DMN; including medial frontal-parietal cortices) and executive control network (ECN; including lateral frontal-parietal cortices) compared with visual and sensorimotor networks. Moreover, the relationship was connection-distance dependent; i.e., rCBF correlated stronger with long-range hubs than short-range ones. It is notable that several DMN and ECN regions exhibited higher rCBF per unit connectivity strength (rCBF/FCS ratio); whereas, this index was lower in posterior visual areas. During the working-memory experiment, both FCS-rCBF coupling and rCBF/FCS ratio were modulated by task load in the ECN and/or DMN regions. Finally, task-induced changes of FCS and rCBF in the lateral-parietal lobe positively correlated with behavioral performance. Together, our results indicate a tight coupling between blood supply and brain functional topology during rest and its modulation in response to task demands, which may shed light on the physiological basis of human brain functional connectome. |
| URI | http://hdl.handle.net/20.500.11897/392093 |
| ISSN | 0027-8424 |
| DOI | 10.1073/pnas.1214900110 |
| Indexed | SCI(E) |
| Appears in Collections: | 医学物理和工程北京市重点实验室 |
