| Title | Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars |
| Authors | Li, Mingzhou Tian, Shilin Jin, Long Zhou, Guangyu Li, Ying Zhang, Yuan Wang, Tao Yeung, Carol K. L. Chen, Lei Ma, Jideng Zhang, Jinbo Jiang, Anan Li, Ji Zhou, Chaowei Zhang, Jie Liu, Yingkai Sun, Xiaoqing Zhao, Hongwei Niu, Zexiong Lou, Pinger Xian, Lingjin Shen, Xiaoyong Liu, Shaoqing Zhang, Shunhua Zhang, Mingwang Zhu, Li Shuai, Surong Bai, Lin Tang, Guoqing Liu, Haifeng Jiang, Yanzhi Mai, Miaomiao Xiao, Jian Wang, Xun Zhou, Qi Wang, Zhiquan Stothard, Paul Xue, Ming Gao, Xiaolian Luo, Zonggang Gu, Yiren Z |
| Affiliation | Sichuan Agr Univ, Coll Anim Sci & Technol, Inst Anim Genet & Breeding, Yaan, Peoples R China. Peking Univ, Peking Tsinghua Ctr Life Sci, Biodynam Opt Imaging Ctr BIOPIC, Beijing 100871, Peoples R China. Peking Univ, Sch Life Sci, Beijing 100871, Peoples R China. Novogene Bioinformat Inst, Beijing, Peoples R China. Chongqing Acad Anim Sci, Chongqing, Peoples R China. Yaan Vocat Coll, Yaan, Peoples R China. Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB, Canada. Minist Agr China, Natl Anim Husb Serv, Beijing, Peoples R China. Univ Houston, Dept Biol & Biochem, Houston, TX USA. Southwest Univ Rongchang, Dept Anim Sci, Chongqing, Peoples R China. Sichuan Anim Sci Acad, Chengdu, Sichuan, Peoples R China. China Agr Univ, Natl Engn Lab Anim Breeding, Coll Biol Sci, State Key Lab Agrobiotechnol, Beijing 100094, Peoples R China. Chinese Acad Agr Sci, Inst Anim Sci, Beijing 100193, Peoples R China. |
| Keywords | HIGH-FIBER DIETS HIGH-ALTITUDE HUMAN-POPULATIONS BEHAVIOR HYPOXIA ADAPTATION EVOLUTION SOWS PHYLOGEOGRAPHY HYPERTENSION |
| Issue Date | 2013 |
| Publisher | nature genetics |
| Citation | NATURE GENETICS.2013,45,(12),1431-U180. |
| Abstract | We report the sequencing at 131x coverage, de novo assembly and analyses of the genome of a female Tibetan wild boar. We also resequenced the whole genomes of 30 Tibetan wild boars from six major distributed locations and 18 geographically related pigs in China. We characterized genetic diversity, population structure and patterns of evolution. We searched for genomic regions under selection, which includes genes that are involved in hypoxia, olfaction, energy metabolism and drug response. Comparing the genome of Tibetan wild boar with those of neighboring Chinese domestic pigs further showed the impact of thousands of years of artificial selection and different signatures of selection in wild boar and domestic pig. We also report genetic adaptations in Tibetan wild boar that are associated with high altitudes and characterize the genetic basis of increased salivation in domestic pig. |
| URI | http://hdl.handle.net/20.500.11897/390732 |
| ISSN | 1061-4036 |
| DOI | 10.1038/ng.2811 |
| Indexed | SCI(E) |
| Appears in Collections: | 生命科学学院 |
