| Title | Retinal Nerve Fiber Layer Thickness in a Population of 12-Year-Old Children in Central China Measured by iVue-100 Spectral-Domain Optical Coherence Tomography: The Anyang Childhood Eye Study |
| Authors | Zhu, Bi-Dan Li, Shi-Ming Li, He Liu, Luo-Ru Wang, Yang Yang, Zhou Li, Si-Yuan Kang, Meng-Tian Fu, Jing Qi, Yan-Hua Zhan, Si-Yan Wang, Ningli |
| Affiliation | Tongzhou Maternal & Child Hlth Hosp Beijing, Dept Ophthalmol, Beijing, Peoples R China. Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing, Peoples R China. Anyang Eye Hosp, Anyang, Henan Province, Peoples R China. Harbin Med Univ, Affiliated Hosp 2, Dept Ophthalmol, Harbin 150086, Peoples R China. Peking Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Beijing 100871, Peoples R China. |
| Keywords | retinal nerve fiber layer thickness iVue-100 Chinese children spectral-domain optical coherence tomography BODY-MASS INDEX AXIAL LENGTH OCT GLAUCOMA AGE PREVALENCE PARAMETERS DISC DETERMINANTS GENDER |
| Issue Date | 2013 |
| Publisher | investigative ophthalmology visual science |
| Citation | INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.2013,54,(13),8104-8111. |
| Abstract | PURPOSE. To study the distribution of peripapillary retinal nerve fiber layer (RNFL) thickness in a population of 12-year-old children in central China using iVue-100 spectral-domain optical coherence tomography (SD-OCT). METHODS. Twelve-year-old students (n = 2105) from four randomly selected middle schools in Anyang, China, participated in the study. Each child underwent ocular examinations, including optical biometry, cycloplegic autorefraction, and SD-OCT (iVue-100). Glaucoma optic nerve head scan was performed to measure RNFL thickness. Only the children with a signal strength index higher than 45 were included in the analyses. Multivariate analyses were performed to examine the association of RNFL with demographic variables (e.g., sex, age, and body mass index [BMI]) and ocular variables (e.g., axial length and refractive error). RESULTS. Optical coherence tomography scans of adequate quality were available for 1955 children (92.9%). The mean (SD) RNFL thickness was 103.08 (9.01) mu m, with the mean (SD) thickest RNFL in the inferior quadrant (129.34 [14.90] mu m), followed by the superior (126.19 [15.24] mu m), temporal (82.98 [10.57] mu m), and nasal (73.82 [13.89] mu m) quadrants. The RNFL was thicker with shorter axial length (beta = -1.53, P < 0.0001) and with higher hyperopia (beta = 0.90, P < 0.0001). Girls had slightly thicker average RNFL thickness than boys (P < 0.0001). The RNFL thickness had no significant correlation with age or BMI. CONCLUSIONS. This study establishes normative peripapillary RNFL values of 12-year-old Chinese children as measured by iVue-100 SD-OCT. The RNFL thickness decreased significantly with increasing axial length and higher myopia. |
| URI | http://hdl.handle.net/20.500.11897/390679 |
| ISSN | 0146-0404 |
| DOI | 10.1167/iovs.13-11958 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
