| Title | Emergence of Community-Acquired Adenovirus Type 55 as a Cause of Community-Onset Pneumonia |
| Authors | Cao, Bin Huang, Guo-Hong Pu, Zeng-Hui Qu, Jiu-Xin Yu, Xiao-Min Zhu, Zhen Dong, Jian-Ping Gao, Yan Zhang, Yong-Xiang Li, Xiao-Hui Liu, Jian-Hua Wang, Hong Xu, Qian Li, Hui Xu, Wenbo Wang, Chen |
| Affiliation | Capital Med Univ, Beijing Inst Resp Med, Beijing Chao Yang Hosp, Dept Infect Dis & Clin Microbiol, Beijing 100020, Peoples R China. Capital Med Univ, Beijing Inst Resp Med, Beijing Chao Yang Hosp, Dept Resp & Crit Care Med, Beijing 100020, Peoples R China. Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China. YanTai Yu Huang Ding Hosp, Yantai, Shan Dong Provi, Peoples R China. Capital Med Univ, Lu He Hosp, Beijing 100020, Peoples R China. Capital Med Univ, Beijing Friendship Hosp, Beijing 100020, Peoples R China. Beijing Hai Dian Hosp, Beijing, Peoples R China. Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China. Beijing Da Xing Hosp, Beijing, Peoples R China. Beijing Huai Rou Hosp, Beijing, Peoples R China. Minist Hlth, China Japan Friendship Hosp, Beijing, Peoples R China. Minist Hlth, Beijing Hosp, Inst Resp Med, Beijing, Peoples R China. Beijing Key Lab Resp & Pulm Circulat Disorders, Beijing, Peoples R China. Xinjiang Med Univ, Urumqi, Peoples R China. Capital Med Univ, Beijing Inst Resp Med, Beijing Chao Yang Hosp, Gong Ti S Rd 8, Beijing 100020, Peoples R China. |
| Keywords | ACUTE RESPIRATORY-DISEASE SEROTYPE 14 ADULTS OUTBREAK INFECTION ETIOLOGY PATHOGEN VIRUSES CHINA CAMP |
| Issue Date | 2014 |
| Publisher | chest |
| Citation | CHEST.2014,145,(1),79-+. |
| Abstract | Background: Since 2008, severe cases of emerging human adenovirus (HAdV) type 55 (HAdV-55) were reported sporadically in China. But no comparative studies had been conducted to discern the differences in epidemiologic and clinical abnormalities between HAdV-55 and other types (HAdV-7, HAdV-3, HAdV-14, HAdV-50, and HAdV-C). Methods: A multicenter surveillance study for adult and adolescent community-acquired pneumonia (CAP) was conducted prospectively in Beijing and Yan Tai between November 2010 and April 2012. A standardized data form was used to record clinical information. The viral DNA extracted from the clinical samples or adenovirus viral isolates was sequenced. Results: Among 969 cases, 48 (5%) were identified as adenovirus pneumonia. Six branches were clustered: HAdV-55 in 21, HAdV-7 in 11, HAdV-3 in nine, HAdV-14 in four, HAdV-50 in two, and HAdV-C in one. Most HAdV-55 cases were identified during February and March. All the hypervariable regions of the hexon genes of the 21 HAdV-55 strains were completely identical. Patients who had HAdV-55 were about 10 years older (P = .027) and had higher pneumonia severity index scores (P = .030) compared with those with other types (HAdV-7, HAdV-3, HAdV-14, HAdV-50, and HAdV-C). Systemic BP was also higher among patients in the HAdV-55 group (P = .006). Unilateral or bilateral consolidations were the most common radiologic findings in both patients with HAdV-55 and those with other types (57.9% vs 36%). More than one-half of the patients were admitted to hospital; oxygen therapy was given to 29.2% of the 48 patients, and two needed mechanical ventilation. Conclusions: HAdV-55 has established itself as a major pneumonia pathogen in the Chinese population, and further surveillance and monitoring of this agent as a cause of CAP is warranted. |
| URI | http://hdl.handle.net/20.500.11897/390629 |
| ISSN | 0012-3692 |
| DOI | 10.1378/chest.13-1186 |
| Indexed | SCI(E) |
| Appears in Collections: | 人民医院 |
