| Title | Activation and Regulation of Caspase-6 and Its Role in Neurodegenerative Diseases |
| Authors | Wang, Xiao-Jun Cao, Qin Zhang, Yan Su, Xiao-Dong |
| Affiliation | Peking Univ, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China. Peking Univ, Biodynam Opt Imaging Ctr BIOPIC, Beijing 100871, Peoples R China. Peking Univ, Sch Life Sci, Beijing 100871, Peoples R China. |
| Keywords | caspase-6 neurodegeneration Alzheimer's disease Huntington's disease regulation mechanism AMYLOID PRECURSOR PROTEIN C-TERMINAL CLEAVAGE YAC128 MOUSE MODEL ALZHEIMERS-DISEASE HUNTINGTONS-DISEASE MUTANT HUNTINGTIN TRANSGENIC MICE AXONAL DEGENERATION IN-VITRO INDUCED APOPTOSIS |
| Issue Date | 2015 |
| Citation | ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55.2015,55,553-572. |
| Abstract | Caspases, a family of cysteine proteases, are major mediators of apoptosis and inflammation. Caspase-6 is classified as an apoptotic effector, and it mediates nuclear shrinkage during apoptosis, but it possesses unique activation and regulation mechanisms that differ from those of other effector caspases. Furthermore, increasing evidence has shown that caspase-6 is highly involved in axon degeneration and neurodegenerative diseases, such as Huntington's disease and Alzheimer's disease. Cleavage at the caspase-6 site in mutated huntingtin protein is a prerequisite for the development of the characteristic behavioral and neuropathological features of Huntington's disease. Active caspase-6 is present in early stages of Alzheimer's disease, and caspase-6 activity is associated with the disease's pathological lesions. In this review, we discuss the evidence relevant to the role of caspase-6 in neurodegenerative diseases and summarize its activation and regulation mechanisms. In doing so, we provide new insight about potential therapeutic approaches that incorporate the modulation of caspase-6 function for the treatment of neurodegenerative diseases. |
| URI | http://hdl.handle.net/20.500.11897/387201 |
| ISSN | 0362-1642 |
| DOI | 10.1146/annurev-pharmtox-010814-124414 |
| Indexed | SCI(E) |
| Appears in Collections: | 生物医学前沿创新中心 生命科学学院 |
