| Title | Roles of aurora kinases in mitosis and tumorigenesis |
| Authors | Fu, Jingyan Bian, Minglei Jiang, Qing Zhang, Chuanmao |
| Affiliation | Peking Univ, Coll Life Sci, Minist Educ, Key Lab Cell Proliferat & Differentiat, Beijing 100871, Peoples R China. Peking Univ, Coll Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China. |
| Keywords | CAENORHABDITIS-ELEGANS EMBRYOS CHROMOSOMAL PASSENGER PROTEIN SPINDLE ASSEMBLY CHECKPOINT HISTONE H3 PHOSPHORYLATION SUPPRESSES TUMOR-GROWTH SQUAMOUS-CELL CARCINOMA A KINASE MITOTIC SPINDLE B KINASE CLEAVAGE FURROW |
| Issue Date | 2007 |
| Publisher | molecular cancer research |
| Citation | MOLECULAR CANCER RESEARCH.2007,5,(1),1-10. |
| Abstract | Aurora kinases, which have been implicated in several vital events in mitosis, represent a protein kinase family highly conserved during evolution. The activity of Aurora kinases is delicately regulated, mainly by phosphorylation and degradation. Deregulation of Aurora kinase activity can result in mitotic abnormality and genetic instability, leading to defects in centrosome function, spindle assembly, chromosome alignment, and cytokinesis. Both the expression level and the kinase activity of Aurora kinases are found to be up-regulated in many human cancers, indicating that these kinases might serve as useful targets for the development of anticancer drugs. This review focuses on recent progress on the roles of Aurora kinases in mitosis and tumorigenesis. |
| URI | http://hdl.handle.net/20.500.11897/345504 |
| ISSN | 1541-7786 |
| DOI | 10.1158/1541-7786.MCR-06-0208 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 生命科学学院 细胞增殖分化调控机理研究教育部重点实验室 |
