| Title | Regulatory effects of hydrogen sulfide on IL-6, IL-8 and IL-10 levels in the plasma and pulmonary tissue of rats with acute lung injury |
| Authors | Li, Tianshui Zhao, Bin Wang, Cong Wang, Haiying Liu, Zhiwei Li, Wang Jin, Hongfang Tang, Chaoshu Du, Junbao |
| Affiliation | Peking Univ, First Hosp, Dept Pediat, Beijing 100034, Peoples R China. Peking Univ, Fourth Hosp, Dept Emergency, Beijing 100034, Peoples R China. Peking Univ, Hlth Sci Ctr, Beijing 100034, Peoples R China. Minist Educ China, Kev Lab Mol Cardiol, Beijing, Peoples R China. |
| Keywords | hydrogen sulfide acute lung injury interleukin polymorphonuclear RESPIRATORY-DISTRESS-SYNDROME NF-KAPPA-B ACUTE-PANCREATITIS OLEIC-ACID INFLAMMATORY MEDIATORS LETHAL ENDOTOXEMIA SYNDROME ARDS NITRIC-OXIDE TNF-ALPHA INTERLEUKIN-6 |
| Issue Date | 2008 |
| Publisher | experimental biology and medicine |
| Citation | EXPERIMENTAL BIOLOGY AND MEDICINE.2008,233,(9),1081-1087. |
| Abstract | We examined the possible role of hydrogen sulfide (H(2)S) in the pathogenesis of oleic acid (OA)-induced acute lung injury (ALI) and its regulatory effects on the inflammatory response. Compared to control rats, the OA-treated rats had decreased partial pressure of oxygen in the arterial blood (PaO(2)) levels, an increased pulmonary wet/dry weight (W/D) ratio, increased index of quantitative assessment (IQA) score and increased frequency of polymorphonuclear (PMN) cells in the lung 2, 4 or 6 h after OA injection (0.1 ml/kg, intravenous injection). In addition, significantly increased IL-6, IL-8 and IL-10 levels together with decreased H(2)S levels were observed in the plasma and lung tissue of CA-treated rats compared to controls. Administration of the H(2)S donor sodium hydrosulfide (NaHS, 56 mu mol/L, intraperitoneal injection) into OA-treated rats increased the PaO(2) level, reduced the lung W/D ratio and infiltration of PMN cells, and alleviated the degree of ALI (measured by the IQA score). In addition, NaHS decreased IL-6 and IL-8 levels but increased IL-10 levels in the plasma and lung tissues, suggesting that H(2)S may regulate the inflammatory response during ALI via regulation of IL-6, IL-8 and IL-10. Thus, the down-regulation of endogenous H(2)S production might be involved in the pathogenesis of OA-induced ALI in rats. |
| URI | http://hdl.handle.net/20.500.11897/345349 |
| ISSN | 1535-3702 |
| DOI | 10.3181/0712-RM-354 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第一医院 北京积水潭医院 |
