| Title | Flickering calcium microdomains signal turning of migrating cells |
| Authors | Wei, Chaoliang Wang, Xianhua Chen, Min Ouyang, Kunfu Zheng, Ming Cheng, Heping |
| Affiliation | Peking Univ, Inst Mol Med, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China. |
| Keywords | calcium microdomains calcium flickers cell migration TRPM7 inositol-1,4,5-trisphosphate receptor confocal microscopy DEPENDENT PROTEASE CALPAIN GROWTH CONES CHANNELS FIBROBLASTS CHEMOTAXIS ADHESION GUIDANCE SPARKS KINASE MUSCLE |
| Issue Date | 2010 |
| Citation | CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY.2010/2/1,88(105-110). |
| Abstract | It has been well-established that polarized migrating cells exhibit a stable and transient gradient of intracellular calcium concentration ([Ca(2+)](i)), increasing from front-to-rear, that is thought to be responsible for rear retraction. The paradox that arises is how calcium at the front of a cell catalyzes critical high-threshold calcium-dependent processes during cell migration and particularly in decision-making for a cell to turn. In this brief review, we discuss the recent discovery of flickering high-[Ca(2+)](i) microdomains ("calcium flickers") at the front of migrating fibroblasts and their common role in transducing local membrane mechanical stress (via TRPM7, a stretch-activated calcium-permeating transient receptor potential channel) and chemoattractant-elicited signals (via type 2 inositol 1,4,5-trisphosphate receptor in the endoplasmic reticulum). Furthermore, we present a new model for patterned calcium flicker activity as the mechanism for steering the turning of a migrating cell. |
| URI | http://hdl.handle.net/20.500.11897/344559 |
| ISSN | 0008-4212 |
| DOI | 10.1139/Y09-118 |
| Indexed | SCI(E) CPCI-S(ISTP) PubMed |
| Appears in Collections: | 分子医学研究所 |
