| Title | Human Papillomavirus Infection and Esophageal Squamous Cell Carcinoma: A Case-Control Study |
| Authors | Guo, Fangcen Liu, Ying Wang, Xueqian He, Zhonghu Weiss, Noel S. Madeleine, Margaret M. Liu, Fangfang Tian, Xiuyun Song, Yuqin Pan, Yaqi Ning, Tao Yang, Haijun Shi, Xiaotian Lu, Changdong Cai, Hong Ke, Yang |
| Affiliation | Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ,Laab Genet, Beijing 100042, Peoples R China. Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. Fred Hutch Inson Canc Res Ctr, Program Epidemiol, Seattle, WA USA. Anyang Canc Hosp, Anyang, Henan, Peoples R China. Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ,Laab Genet, 52 Fucheng Rd, Beijing 100042, Peoples R China. |
| Keywords | HIGH-RISK REGION POLYMERASE-CHAIN-REACTION GASTRIC CANCERS NO ASSOCIATION HPV DNA CHINA COHORT PREVALENCE SEROLOGY SMOKING |
| Issue Date | 2012 |
| Publisher | cancer epidemiology biomarkers prevention |
| Citation | CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION.2012,21,(5),780-785. |
| Abstract | Background: The risk factors for esophageal squamous cell carcinoma (ESCC) in the high-incidence areas of China remain unclear. Methods: A total of 300 patients with ESCC and 900 controls matched for age and sex were enrolled in Anyang (China), a high-risk area for ESCC in China. In tumor tissue of the cases and in esophageal biopsies of controls, the presence of human papillomavirus (HPV) DNA was assessed by an SPF1/GP6(+)-mediated PCR followed by sequencing. The presence of serum antibody against the HPV-16 E7 oncoprotein was assessed by use of the ELISA. ORs with 95% confidence intervals (CI) were calculated via unconditional logistic regression models. Results: The presence of HPV in the esophagus (OR, 6.4; 95% Cl, 4.4-9.2) was associated with increased risk of ESCC. Moreover, infection with "oncogenic" types of HPV (OR, 10.3; 95% Cl, 6.3-16.8) was more strongly associated with ESCC than other types of HPV (OR, 2.4; 95% Cl, 1.4-4.2). The presence of HPV-16 (OR, 12.8; 95% Cl, 7.6-21.7) was particularly strongly associated with ESCC. In addition, a higher proportion of cases than controls had serum antibodies against HPV-16 E7 (OR, 6.1; 95% CI, 3.7-10.0). Conclusion and Impact: This study provides the strongest epidemiologic evidence to date in support of the important role of HPV in the development of ESCC in high-incidence areas of China. Cancer Epidemiol Biomarkers Prey; 21(5); 780-5. (C)2012 AACR. |
| URI | http://hdl.handle.net/20.500.11897/343873 |
| ISSN | 1055-9965 |
| DOI | 10.1158/1055-9965.EPI-11-1206 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 北京肿瘤医院 |
