| Title | Autophagy process is associated with anti-neoplastic function |
| Authors | Wang, Chong Wang, Yachen McNutt, Michael A. Zhu, Wei-Guo |
| Affiliation | Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Biochem & Mol Biol, Hlth Sci Ctr,Minist Educ, Beijing 100191, Peoples R China. Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China. |
| Keywords | autophagy cancer Beclin 1 FoxO mTOR p53 INTERACTING FACTOR-I TUMOR-SUPPRESSOR ACTIVITY DROSOPHILA FAT-BODY CELL-DEATH PROTEIN-KINASE PHOSPHATIDYLINOSITOL 3-KINASE TRANSCRIPTION FACTORS DECREASED EXPRESSION REGULATES AUTOPHAGY CYTOSOLIC FOXO1 |
| Issue Date | 2011 |
| Publisher | acta biochimica et biophysica sinica |
| Citation | ACTA BIOCHIMICA ET BIOPHYSICA SINICA.2011,43,(6),425-432. |
| Abstract | Autophagy is a highly conserved process of cellular degradation, which is present in yeast, plants, and mammals. Under normal physiological conditions, autophagy acts to maintain cellular homeostasis and regulate the turnover of organelles. In response to cellular stresses, autophagy prevents the accumulation of impaired proteins and organelles, which serves to inhibit carcinogenesis. On this basis, it is widely accepted that most tumor suppressors, such as beclin 1 associated proteins, forkhead box class O (FoxO) family proteins, multiple mammalian target of Rapamycin (mTOR) inactivators, and nuclear p53 play a role in inducing autophagy. Here, we focus on how the process of autophagy is associated with anti-neoplastic function. |
| URI | http://hdl.handle.net/20.500.11897/343820 |
| ISSN | 1672-9145 |
| DOI | 10.1093/abbs/gmr028 |
| Indexed | SCI(E) PubMed 中国科技核心期刊(ISTIC) 中国科学引文数据库(CSCD) |
| Appears in Collections: | 医学部待认领 |
