| Title | Applications of post-translational modifications of FoxO family proteins in biological functions |
| Authors | Zhao, Ying Wang, Yachen Zhu, Wei-Guo |
| Affiliation | Peking Univ, Dept Biochem & Mol Biol, Hlth Sci Ctr, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100191, Peoples R China. Peking Univ, Sch Oncol, Hlth Sci Ctr, Beijing 100191, Peoples R China. |
| Keywords | FoxO post-translational modification cancer FORKHEAD TRANSCRIPTION FACTOR UBIQUITIN-MEDIATED DEGRADATION EXTENDS LIFE-SPAN OXIDATIVE-STRESS DNA-BINDING SUBCELLULAR-LOCALIZATION PROTEASOMAL DEGRADATION PROMOTES TUMORIGENESIS DEPENDENT REGULATION SIGNALING PATHWAY |
| Issue Date | 2011 |
| Publisher | 分子细胞生物学报 |
| Citation | JOURNAL OF MOLECULAR CELL BIOLOGY.2011,3,(5),276-282. |
| Abstract | The functions of the FoxO family proteins, in particular their transcriptional activities, are modulated by post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, methylation and glycosylation. These PTMs occur in response to different cellular stresses, which in turn regulate the subcellular localization of FoxO family proteins, as well as their half-life, DNA binding, transcriptional activity and ability to interact with other cellular proteins. In this review, we summarize the role of PTMs of FoxO family proteins in linking their biological and functional relevance with various diseases. |
| URI | http://hdl.handle.net/20.500.11897/343694 |
| ISSN | 1674-2788 |
| DOI | 10.1093/jmcb/mjr013 |
| Indexed | SCI(E) PubMed 中国科学引文数据库(CSCD) |
| Appears in Collections: | 北京肿瘤医院 |
