| Title | Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects |
| Authors | Ren, Aiguo Qiu, Xinghua Jin, Lei Ma, Jin Li, Zhiwen Zhang, Le Zhu, Huiping Finnell, Richard H. Zhu, Tong |
| Affiliation | Peking Univ, Inst Reprod & Child Hlth, Hlth Sci Ctr, Beijing 100191, Peoples R China. Peking Univ, Minist Hlth, Key Lab Reprod Hlth, Beijing 100191, Peoples R China. Peking Univ, State Key Joint Lab Environm Simulat & Pollut Con, Coll Environm Sci & Engn, Beijing 100871, Peoples R China. Peking Univ, Ctr Environm & Hlth, Beijing 100871, Peoples R China. Univ Texas Austin, Dell Pediat Res Inst, Dept Nutr Sci, Austin, TX 78723 USA. Univ Texas Austin, Dept Chem & Biochem, Austin, TX 78723 USA. |
| Keywords | congenital abnormalities indoor air pollution POLYCYCLIC AROMATIC-HYDROCARBONS MATERNAL PESTICIDE EXPOSURE CONGENITAL-ANOMALIES OXIDATIVE STRESS POPULATION HYPERTHERMIA CANCER DAMAGE FEVER CHINA |
| Issue Date | 2011 |
| Publisher | proceedings of the national academy of sciences of the united states of america |
| Citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.2011,108,(31),12770-12775. |
| Abstract | Persistent organic pollutants (POPs) have been associated with a wide range of adverse health effects. Our case-control study was performed to explore the association between placental levels of selected POPs and risks for neural tube defects (NTDs) in a Chinese population with a high prevalence of NTDs. Cases included 80 fetuses or newborns with NTDs, whereas the controls were 50 healthy, nonmalformed newborn infants. Placental concentrations of polycyclic aromatic hydrocarbons (PAHs), organochlorine pesticides, polychlorinated biphenyls, and polybrominated diphenyl ethers were analyzed by gas chromatography-mass spectrometry. The medians of PAHs, o,p'-isomers of dichlorodiphenyltrichloroethane (DDT) and metabolites, alpha- and gamma-hexachlorocyclohexane (HCH), and alpha-endosulfan were significantly higher in case placentas than in controls. PAH concentrations above the median were associated with a 4.52-fold (95% confidence interval (CI), 2.10-9.74) increased risk for any NTDs, and 5.84-(95% CI, 2.28-14.96) and 3.71-fold (95% CI, 1.57-8.79) increased risks for anencephaly and spina bifida, respectively. A dose-response relationship was observed between PAH levels and the risk of NTDs, with odds ratios for the second, third, and fourth quartiles, compared with the first, of 1.77-(95% CI, 0.66-4.76), 3.83-(95% CI, 1.37-10.75), and 11.67-fold (95% CI, 3.28-41.49), respectively. A dose-response relationship was observed for anencephaly and spina bifida subtypes. Similar results were observed for o,p'-DDT and metabolites, alpha-HCH, gamma-HCH, and alpha-endosulfan, whereas no dose-response relationship was observed for the last two pollutants. Elevated placental concentrations of PAHs, o,p'-DDT and metabolites, and alpha-HCH were associated with increased risks of NTDs in this population. |
| URI | http://hdl.handle.net/20.500.11897/343644 |
| ISSN | 0027-8424 |
| DOI | 10.1073/pnas.1105209108 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 公共卫生学院 环境科学与工程学院 环境模拟与污染控制国家重点联合实验室 |
