| Title | Low density lipoprotein cholesterol level inversely correlated with coronary flow velocity reserve in patients with Type 2 diabetes |
| Authors | Yu, Jie Han, Jiang-Li He, Li-Yun Feng, Xin-Heng Li, Wei-Hong Mao, Jie-Ming Gao, Wei Wang, Guang |
| Affiliation | Peking Univ, Dept Cardiol, Hosp 3, Key Lab Mol Cardiovasc Sci,Minist Educ, Beijing 100871, Peoples R China. Capital Med Univ, Beijing Chaoyang Hosp, Dept Endocrinol, Beijing 100020, Peoples R China. |
| Keywords | Coronary flow velocity reserve Low-density lipoprotein cholesterol Endothelial function Diabetes mellitus High-density lipoprotein cholesterol DEPENDENT VASORELAXATION NONINVASIVE ASSESSMENT MICROVASCULAR FUNCTION ENDOTHELIAL FUNCTION LDL CHOLESTEROL HDL CHOLESTEROL ECHOCARDIOGRAPHY VASODILATION DYSFUNCTION STENOSIS |
| Issue Date | 2013 |
| Publisher | journal of geriatric cardiology |
| Citation | JOURNAL OF GERIATRIC CARDIOLOGY.2013,10,(2),159-164. |
| Abstract | Objectives To evaluate the association of coronary artery endothelial function and plasma levels of low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) in patients with Type 2 Diabetes Mellitus (DM). Methods We investigated 90 participants from our institution between October 2007 to March 2010: non-DM (n = 60) and DM (n = 30). As an indicator of coronary endothelial dysfunction, we used non-invasive Doppler echocardiography to quantify coronary flow velocity reserve (CFVR) in the distal part of the left descending artery after rest and after intravenous adenosine administration. Results Plasma level of LDL-C was significantly higher in patients with DM than in non-DM (3.21 +/- 0.64 vs. 2.86 +/- 0.72 mmo/L, P < 0.05), but HDL-C level did not differ between the groups (1.01 +/- 0.17 vs. 1.05 +/- 0.19 mmo/L). Furthermore, the CFVR value was lower in DM patients than non-diabetics (2.45 +/- 0.62 vs. 2.98 +/- 0.68, P < 0.001). Plasma levels of LDL-C were negatively correlated with CFVR in all subjects (r = -0.35, P < 0.001; 95% confidence interval (CI): -0.52 - -0.15) and in the non-DM (r = -0.29, P < 0.05; 95% CI: -0.51 - -0.05), with an even stronger negative correlation in the DM group (r = -0.42, P < 0.05; 95% CI: -0.68 - -0.06). Age (beta = -0.019, s = 0.007, s beta = -0.435, 95% CI: -0.033 - -0.005, P = 0.008), LDL-C (beta = -0.217, s = 0.105, s beta = -0.282, 95% CI: -0.428 - -0.005, P = 0.045) remained independently correlated with CFVR in the DM group. However, we found no correlation between HDL-C level and CFVR in any group. Conclusions Diabetes may contribute to coronary artery disease (CAD) by inducing dysfunction of the coronary artery endothelium. Increased LDL-C level may adversely impair coronary endothelial function in DM. HDL-C may lose its endothelial-protective effects, in part as a result of pathological conditions, especially under abnormal glucose metabolism. |
| URI | http://hdl.handle.net/20.500.11897/342812 |
| ISSN | 1671-5411 |
| DOI | 10.3969/j.issn.1671-5411.2013.02.007 |
| Indexed | SCI(E) PubMed 中国科学引文数据库(CSCD) |
| Appears in Collections: | 第三医院 |
