| Title | Effects of Helicobacter pylori Treatment on Gastric Cancer Incidence and Mortality in Subgroups |
| Authors | Li, Wen-Qing Ma, Jun-Ling Zhang, Lian Brown, Linda M. Li, Ji-You Shen, Lin Pan, Kai-Feng Liu, Wei-Dong Hu, Yuanreng Han, Zhong-Xiang Crystal-Mansour, Susan Pee, David Blot, William J. Fraumeni, Joseph F., Jr. You, Wei-Cheng Gail, Mitchell H. |
| Affiliation | NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. Peking Univ, Canc Hosp & Inst, Dept Canc Epidemiol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China. RTI Int, Rockville, MD USA. Linqu Cty Publ Hlth Bur, Linqu, Shandong, Peoples R China. WESTAT Corp, Rockville, MD 20850 USA. Informat Management Serv Inc, Rockville, MD USA. Int Epidemiol Inst, Rockville, MD USA. Vanderbilt Univ, Dept Med Epidemiol, Nashville, TN 37235 USA. NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr,Rm 7E138, Rockville, MD 20890 USA. |
| Keywords | RANDOMIZED CONTROLLED-TRIAL HIGH-RISK FACTORIAL TRIAL LESIONS ERADICATION POPULATION REDUCE CHINA |
| Issue Date | 2014 |
| Publisher | jnci journal of the national cancer institute |
| Citation | JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE.2014,106,(7). |
| Abstract | Among 2258 Helicobacter pylori-seropositive subjects randomly assigned to receive one-time H. pylori treatment with amoxicillin-omeprazole or its placebo, we evaluated the 15-year effect of treatment on gastric cancer incidence and mortality in subgroups defined by age, baseline gastric histopathology, and post-treatment infection status. We used conditional logistic and Cox regressions for covariable adjustments in incidence and mortality analyses, respectively. Treatment was associated with a statistically significant decrease in gastric cancer incidence (odds ratio = 0.36; 95% confidence interval [CI] = 0.17 to 0.79) and mortality (hazard ratio = 0.26; 95% CI = 0.09 to 0.79) at ages 55 years and older and a statistically significant decrease in incidence among those with intestinal metaplasia or dysplasia at baseline (odds ratio = 0.56; 95% CI = 0.34 to 0.91). Treatment benefits for incidence and mortality among those with and without post-treatment infection were similar. Thus H. pylori treatment can benefit older members and those with advanced baseline histopathology, and benefits are present even with post-treatment infection, suggesting treatment can benefit an entire population, not just the young or those with mild histopathology. |
| URI | http://hdl.handle.net/20.500.11897/342120 |
| ISSN | 0027-8874 |
| DOI | 10.1093/jnci/dju116 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 北京肿瘤医院 |
